bwa-mem2
IntaRNA
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bwa-mem2 | IntaRNA | |
---|---|---|
2 | 1 | |
676 | 44 | |
1.8% | - | |
2.6 | 6.6 | |
4 months ago | 3 months ago | |
C++ | C++ | |
GNU General Public License v3.0 or later | GNU General Public License v3.0 or later |
Stars - the number of stars that a project has on GitHub. Growth - month over month growth in stars.
Activity is a relative number indicating how actively a project is being developed. Recent commits have higher weight than older ones.
For example, an activity of 9.0 indicates that a project is amongst the top 10% of the most actively developed projects that we are tracking.
bwa-mem2
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Anyone use DRAGEN-GATK?
If you haven’t heard of it already you may want to check out https://github.com/bwa-mem2/bwa-mem2 which is a faster version of bwa-mem. I’ve been using it for a while now and found it to be quite stable, same results as the original and the speed improvement is nice.
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Software Development Project
I’ve recently switched to bwa mem2 and the speed increase is nice for what is basically a drop in replacement (after a bit of validation to make sure that was true). https://github.com/bwa-mem2/bwa-mem2
IntaRNA
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IntaRNA optimization
There might be, the code is open source (https://github.com/BackofenLab/IntaRNA/) so just download it, and run it through a code profiler, see where most of the runtime is spend and optimise the code.
What are some alternatives?
minimap2 - A versatile pairwise aligner for genomic and spliced nucleotide sequences
salmon - 🐟 🍣 🍱 Highly-accurate & wicked fast transcript-level quantification from RNA-seq reads using selective alignment
bowtie2 - A fast and sensitive gapped read aligner
minimap2 - A versatile pairwise aligner for genomic and spliced nucleotide sequences
algo-ds-101 - algo-ds-101
htslib - C library for high-throughput sequencing data formats
Node-and-express-structure-using-cpp
edlib - Lightweight, super fast C/C++ (& Python) library for sequence alignment using edit (Levenshtein) distance.
seq - A high-performance, Pythonic language for bioinformatics
vg - tools for working with genome variation graphs
fastp - An ultra-fast all-in-one FASTQ preprocessor (QC/adapters/trimming/filtering/splitting/merging...)