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Top 12 C++ Genomic Projects
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Vcflib
C++ library and cmdline tools for parsing and manipulating VCF files with python and zig bindings
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amr
AMRFinderPlus - Identify AMR genes and point mutations, and virulence and stress resistance genes in assembled bacterial nucleotide and protein sequence.
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TileDB-VCF
Efficient variant-call data storage and retrieval library using the TileDB storage library.
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NOTE:
The open source projects on this list are ordered by number of github stars.
The number of mentions indicates repo mentiontions in the last 12 Months or
since we started tracking (Dec 2020).
C++ Genomics discussion
C++ Genomics related posts
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NHI Genome Studies: Mexico Govt Sept 12 Congressional hearing
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Help running hap.py
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Has anyone stored/queried VCFs and their variant records in a relational database?
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Anyone use DRAGEN-GATK?
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VG v1.36.0 just released!
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[TileDB webinar] Population genomics is a data management problem
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Bioinformatics programming language
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A note from our sponsor - SaaSHub
www.saashub.com | 11 Jun 2026
Index
What are some of the best open-source Genomic projects in C++? This list will help you:
| # | Project | Stars |
|---|---|---|
| 1 | vg | 1,322 |
| 2 | bwa-mem2 | 837 |
| 3 | bowtie2 | 793 |
| 4 | megahit | 719 |
| 5 | Vcflib | 679 |
| 6 | hap.py | 469 |
| 7 | amr | 370 |
| 8 | octopus | 323 |
| 9 | bowtie | 267 |
| 10 | GenomicSQLite | 170 |
| 11 | TileDB-VCF | 108 |
| 12 | cryfa | 63 |
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