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You must build it yourself with Tauri (https://tauri.app) or use pre-built releases, which you can download here: https://github.com/btpf/Alexandria/releases
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SaaSHub
SaaSHub - Software Alternatives and Reviews. SaaSHub helps you find the best software and product alternatives
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Calibre can do this: https://calibre-ebook.com
Here's the help page on setting up your own content server: https://manual.calibre-ebook.com/#the-calibre-content-server
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A few days ago I discovered https://github.com/ealang/pixel-reader which lets you read EPUB-s on the Miyoo Mini Plus retro gaming device with a 3.5" screen. I really enjoy reading on it.
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mupdf is the mupdf of epub; it supports epub and other formats beyond pdf¹. When I've had really large files I've used mupdf to read them a few times, as it seems to be far better at handling them than other tools.
¹ https://mupdf.com/
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You must build it yourself with Tauri (https://tauri.app) or use pre-built releases, which you can download here: https://github.com/btpf/Alexandria/releases
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Kavita
Kavita is a fast, feature rich, cross platform reading server. Built with the goal of being a full solution for all your reading needs. Setup your own server and share your reading collection with your friends and family.
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koreader
An ebook reader application supporting PDF, DjVu, EPUB, FB2 and many more formats, running on Cervantes, Kindle, Kobo, PocketBook and Android devices
It's pretty good. You can highlight a passage and then it pops up a box for you to type in.
However, Lua doesn't support native Android keyboards - so you have to use a virtual keyboard https://github.com/koreader/koreader/issues/7423
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The closest thing I've seen to 'Plex for ebooks' is limited to manga/comics in .cbz/.cbr format: https://github.com/faldez/tanoshi . It's works reasonably well. Probably could be forked to add support for more general purpose reading use cases.
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Calibre Web
:books: Web app for browsing, reading and downloading eBooks stored in a Calibre database
Calibre Web: https://github.com/janeczku/calibre-web