bonito
Prisma
bonito | Prisma | |
---|---|---|
8 | 444 | |
373 | 37,241 | |
0.0% | 0.9% | |
7.3 | 9.9 | |
5 months ago | 8 days ago | |
Python | TypeScript | |
GNU General Public License v3.0 or later | Apache License 2.0 |
Stars - the number of stars that a project has on GitHub. Growth - month over month growth in stars.
Activity is a relative number indicating how actively a project is being developed. Recent commits have higher weight than older ones.
For example, an activity of 9.0 indicates that a project is amongst the top 10% of the most actively developed projects that we are tracking.
bonito
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miRNA Detection
There is a technology called Nanopore. I’ve never used it myself but the concept was to be able to sequence samples of nucleic acid out in the field. A quick pubmed search indicated that it can detect miRNA, but maybe with some modifications. https://nanoporetech.com Best of luck with it!
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Oxford University Press’s new logo is unfathomably bad
> An unpopular opinion: there are too many other logos that look like the original logo
There are also too many logos that look like the new logo. The first blue circle logos that spring to mind are Blue Circle Cement/Tarmac/Lafarge [1] and Oxford Nanopore [2].
[1]: https://en.wikipedia.org/wiki/Tarmac_(company)
[2]: https://nanoporetech.com/
- PORTABLE DNA SEQUENCER!!!!
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Ask HN: Who is hiring? (May 2022)
Oxford Nanopore Technologies (https://nanoporetech.com/) | Front end developer | Full-time | Oxford | Remote (UK)
Oxford Nanopore Technologies is headquartered at the Oxford Science Park outside Oxford, UK, with satellite offices and commercial presence in many global locations across the US, APAC and Europe. Our DNA/RNA sequencing platform is the only technology that offers real-time analysis (for rapid insights), in fully scalable formats from pocket to population scale. Our goal is to enable the analysis of any living thing, by anyone, anywhere.
Tech stack: Electron, Stencil, React, Typescript, RxJS, GRPC
For more details, please email: [email protected]
- El primer genoma completo de un ser humano abre una nueva era en la ciencia
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Buying artificial membranes
Ok this isn't really my area but I know that there are labs/companies performing these types of electrical current disturbance measurements of membrane-type proteins for both DNA sequencing (https://nanoporetech.com/) and protein sequencing (https://www.nature.com/articles/s41587-019-0401-y).
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ELI5: Why home blood tests do not exist, while we can measure our sugar levels with personal devices at home?
Now nanopore sequencing is solid state and gets much longer reads. https://nanoporetech.com/ and https://en.wikipedia.org/wiki/Nanopore_sequencing
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Raw nanowire sequencer data
Also best of luck with the basecaller, I will say that the latest guppy versions are very good, both in terms of accuracy and speed, as they are GPU accelerated and the best I've seen in accuracy. You may also be interested in Bonito, a tool to generate your own GPU basecalling model or tweak existing models to your data. https://github.com/nanoporetech/bonito.
Prisma
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A Software Engineer's Tips and Tricks #1: Drizzle
In the world of software development, there are two kinds of developers: those who have never had to complain about ORMs and those who have actually used them. Whether it’s Django ORM for Python, Active Record for Ruby, GORM for Golang, Doctrine for PHP, or Prisma for TypeScript, a common issue persists: writing simple queries is straightforward, but constructing complex or optimized queries can take hours, if not days.
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Stories Behind ZenStack V2!
Support for a Union type #2505
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Deploy Full-Stack Next.js T3App with Cognito and Prisma using AWS Lambda
generator client { provider = "prisma-client-js" binaryTargets = ["native", "rhel-openssl-1.0.x"] } datasource db { provider = "postgresql" // NOTE: When using mysql or sqlserver, uncomment the @db.Text annotations in model Account below // Further reading: // https://next-auth.js.org/adapters/prisma#create-the-prisma-schema // https://www.prisma.io/docs/reference/api-reference/prisma-schema-reference#string url = env("DATABASE_URL") } model Post { id Int @id @default(autoincrement()) name String createdAt DateTime @default(now()) updatedAt DateTime @updatedAt createdBy User @relation(fields: [createdById], references: [id]) createdById String @@index([name]) } // ... rest of the schema
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End-To-End Polymorphism: From Database to UI, Achieving SOLID Design
Unfortunately Prisma hasn’t supported polymorphism yet. As such, you can't use inheritance to model the entity in the same way as in your programming language, as depicted in the above class diagram. The good news is that we could intimate it using table inheritance to imitate it.
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Next.js App Router Course
In this project I am manually declaring the data types. For better type-safety, use Prisma, which automatically generates types based on your database schema.
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Next.js 14: Fetching Data
When you're creating a full-stack application, you'll also need to write logic to interact with your database. For relational databases like Postgres, you can do this with SQL, or an ORM like Prisma.
- Utilizando Testcontainers para Testes de Integração com NestJS e Prisma ORM
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Building an Admin Console With Minimum Code Using React-Admin, Prisma, and Zenstack
Prisma is a modern TypeScript-first ORM that allows you to manage database schemas easily, make queries and mutations with great flexibility, and ensure excellent type safety.
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How to add Passkey Login to Next.js using NextAuth and Hanko
Prisma
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Taming cross-service database transactions in NestJS with AsyncLocalStorage
There have been multiple feature requests to add native support for AsyncLocalStorage to Prisma, but they haven't been met with much enthusiasm from the maintainers. Some people solved it by extending and overriding the client (which is arguably prone to breaking with updates).
What are some alternatives?
pytorch-tutorial - PyTorch Tutorial for Deep Learning Researchers
Knex - A query builder for PostgreSQL, MySQL, CockroachDB, SQL Server, SQLite3 and Oracle, designed to be flexible, portable, and fun to use.
transformers - 🤗 Transformers: State-of-the-art Machine Learning for Pytorch, TensorFlow, and JAX.
Sequelize - Feature-rich ORM for modern Node.js and TypeScript, it supports PostgreSQL (with JSON and JSONB support), MySQL, MariaDB, SQLite, MS SQL Server, Snowflake, Oracle DB (v6), DB2 and DB2 for IBM i.
NanoSim - Nanopore sequence read simulator
TypeORM - ORM for TypeScript and JavaScript. Supports MySQL, PostgreSQL, MariaDB, SQLite, MS SQL Server, Oracle, SAP Hana, WebSQL databases. Works in NodeJS, Browser, Ionic, Cordova and Electron platforms.
fossa-cli - Fast, portable and reliable dependency analysis for any codebase. Supports license & vulnerability scanning for large monoliths. Language-agnostic; integrates with 20+ build systems.
Mongoose - MongoDB object modeling designed to work in an asynchronous environment.
yolov5 - YOLOv5 🚀 in PyTorch > ONNX > CoreML > TFLite
MikroORM - TypeScript ORM for Node.js based on Data Mapper, Unit of Work and Identity Map patterns. Supports MongoDB, MySQL, MariaDB, MS SQL Server, PostgreSQL and SQLite/libSQL databases.
pipeline-structural-variation - Pipeline for calling structural variations in whole genomes sequencing Oxford Nanopore data
lucid - AdonisJS SQL ORM. Supports PostgreSQL, MySQL, MSSQL, Redshift, SQLite and many more