tenzir VS gnomad-browser

We're building something similar at Tenzir, but more for operational security workloads. https://docs.tenzir.com

Differences to Vector:

- An agent has optional indexed storage, so you can store your data there and pick it up later. The storage is based on Apache Feather, Parquet's little brother.

- Pipelines operators both work with data frames (Arrow record batches) or chunks of bytes.

- Structured pipelines are multi-schema, i.e., a single pipeline can process streams of record batches with different schemas.

Tenzir | Remote (EU) or Hamburg, Germany | open-core | Full-time | https://tenzir.com

Tenzir is hiring several key engineering roles to meet the needs in expanding the team. Our product: security data pipelines. From the data side, think of it as an Arrow-native, multi-schema ETL tool that offers optional storage in Parquet/Feather. From the security perspective, think of it as a solution for collecting, parsing, transforming, aggregating, and routing data. We typically sit between the data sources (endpoint, network, cloud) and sinks (SIEM, data lake).

Our open-source execution engine is C++20 (https://github.com/tenzir/tenzir), our platform is SvelteKit and TypeScript. Experience with data-first frontend apps is a great plus. Open positions at https://tenzir.jobs.personio.de:

    - Fullstack Engineer

We're in the middle of getting TQL v2 [] out of the door with support for expressions and more advanced control flow, e.g., match-case statements. There's a blog post [#] about the core design of the engine as well.

While it's a general-purpose ETL tool, we're targeting primary operational security use case where people today use Splunk, Sentinel/ADX, Elastic, etc. So some operators are very security'ish, like Sigma, YARA, or Velociraptor.

[] https://github.com/tenzir/tenzir/blob/64ef997d736e9416e859bf...

[#] https://docs.tenzir.com/blog/five-design-principles-for-buil...

Hey, founder of Tenzir [1] here — We are building an open-core pipeline-first security data engine that can massively reduce your Splunk costs. Even though we go to market "mid stream" we have a few users that use us as light-weight SIEM (or more accurately, just plain log management).

We are still in early access to browse through our docs or swing by our Discord.

[1] https://tenzir.com | https://docs.tenzir.com

Download VAST v3.1 here: https://github.com/tenzir/vast/releases/tag/v3.1.0

Tenzir is a funded seed-stage startup that builds a next generation data-plane for plug-and-play security operations. Our mission is to empower defenders with an open data engineering platform to perform data-driven investigations through combination best-of-breed solutions. Our stack consists of the high-performance C++20 telemetry engine VAST, a Rust API, and a ReasonML-based frontend.

I had chat with Hannes, the DuckDB co-founder, a few weeks ago. They are building awesome stuff to become the "SQLite of OLAP". The team comes with a strong academic background and is tuned into the data engineering world.

At Tenzir, we looked at DuckDB as embeddable backend engine to do the heavy lifting of query execution of our engine [1]. Our idea is throwing over a set of Parquet files, along with a query; initially SQL but perhaps soon Substrait [2] if it picks up.

We also experiment with a cloud deployment [3] where a different set of I/O path may warrant a different backend engine. Right now, we're working on a serverless approach leveraging Datafusion (and depending on maturity, Ballista at some point).

My hunch is that we will see more pluggability in this space moving forward. It's not only meaningful from an open-core business model perspective, but also pays dividends to the UX. The company that's solving a domain problem (for us: security operations center infrastructre) can leverage a high-bandwidth drop-in engine and only needs to wire it properly. This requires much less data engineers than building a poorman's version of the same inhouse.

We also have the R use case, e.g., to write reports in Rmarkdown that crunch some customer security telemetry, highlighting outliers or other noteworthy events. We're not there yet, but with the right query backend, I would expect to get this almost for free. We're close to being ready to use Arrow Flight for interop, but it's not zero-copy. DuckDB has demonstrated the zero-copy approach recently [4], going through the C API. (The story is also relevant when doing s/R/Python/, FWIW.)

[1] https://github.com/tenzir/vast

To this end, we build the high-performance telemetry engine VAST, which at its core, ingests hundreds of thousands of events per second from high-volume data sources (such as network telemetry as NetFlow, Zeek, Suricata, and endpoint telemetry from various agents). To the user, VAST offers low-latency access through various APIs, and in particular Apache Arrow for high-bandwidth data sharing with downstream tooling. A flexible plugin API enables additional security-specific use cases on top, such as realtime matching of threat intelligence or mining of asset data for passive inventorization.

Tenzir | C++, ReasonML, Rust, Python | Remote | Open-source | Full-time | https://tenzir.com

Tenzir is a funded seed-stage startup that builds a next generation data-plane for plug-and-play security operations. Our mission is to empower defenders with an open platform to perform automated data-driven investigations through combination best-of-breed solutions. Our stack consists of the high-performance C++ database VAST (https://github.com/tenzir/vast), a Rust API, and a ReasonML-based frontend.

Our open engineering positions include:

- Database: https://tenzir.com/career/backend-engineer/

- DevOps: https://tenzir.com/career/devops-platform-engineer/

- Frontend: https://tenzir.com/career/frontend-engineer/

We are based out of Hamburg, Germany, but cultivate an agile remote-first mindset. If you live in the region and look for a System Administrator, we’d love to hear from you!

For any questions, feel free to reach out to us at [email protected].

We at Tenzir (https://tenzir.com/) are an early-stage startup that build a next generation data-plane for modern Security Operations Centers. We are looking for a frontend engineer to help us enhance the web interface to VAST (our open-core telemetry engine, https://github.com/tenzir/vast). In our stack, we use C++ for VAST , Rust and ReasonML (compiled to JS) in our API-Layer, and ReasonML on the frontend. Our website is written in ReasonML with the help of Gatsby. Our team cultivates a mindset of strong typing and functional programming, practiced end-to-end across the entire stack. We're a remote-first company, scattered across Europe. Ideally looking for someone within (+ / -) 4hrs timezone.

try one of these: GnomAD (https://gnomad.broadinstitute.org/) 1000 Genomes (http://browser.1000genomes.org) dbSNP (http://www.ncbi.nlm.nih.gov/snp)

Maybe you can ask the opposite question; what are the bounds of of a functional human being. https://gnomad.broadinstitute.org/ GnomAD is a aggregation of healthy human genetic sequences which was primarily built on the aggregated control groups of many genetic sequencing studies. There are studies of this data analysing the co-occurrence of variants in gnomAD which may help.

Maybe something like this? https://promethease.com/ Clinvar for variants that might be of clinical relevance. https://gnomad.broadinstitute.org/ for allele frequencies & some info about variants.

You could look at aggregation databases such as gnomad https://gnomad.broadinstitute.org/ anything with a frequency incompatible with the disease is likely non pathogenic

Broad Institute of MIT and Harvard | Cambridge, MA | Frontend Software Engineer | REMOTE or HYBRID (New England area)

We are hiring a frontend developer to help lead the next phase of the gnomAD browser, a web application for displaying the world's largest collection of human genome/exome sequences. https://gnomad.broadinstitute.org. Looking for applicants who are excited about data visualization and designing complex interfaces for scientific research.

Apply here: http://broad.io/cq7dw8

Broad Institute of MIT and Harvard | New England | Software Engineer | REMOTE/HYBRID

Our team is focused on building the tools necessary to visualize and interpret massive data sets of human genetic variation and functional genomic information. We have developed gnomAD (https://gnomad.broadinstitute.org), the world’s largest public reference dataset of human exomes and genomes. gnomAD has become one of the most widely used resources in the field, and is now the default reference database for virtually all clinical interpretation pipelines, as well as a standard analysis resource for a wide variety of genetic and biological studies. We estimate gnomAD has contributed to the clinical diagnosis of over 2 million patients with genetic disorders.

Your role will be to maintain the gnomAD browser, our open source web application for exploring gnomAD and related datasets, and develop new scientific functionality as we continue to grow to over 1 million human samples. You will work with a team of software engineers, computational biologists and clinical and research users to develop new features and visualizations that incorporate user feedback. Software engineering skills and an interest in user interface design and data visualization are key. Basic familiarity with genomics and DNA sequencing data is preferred, but not required. Most importantly, the ideal candidate will have enthusiasm for playing a critical role in a team-oriented project and learning new domains.

Minimum Requirements

If you're talking about humans, start with gnomAD: https://gnomad.broadinstitute.org/