gnomad-browser VS webviz

try one of these: GnomAD (https://gnomad.broadinstitute.org/) 1000 Genomes (http://browser.1000genomes.org) dbSNP (http://www.ncbi.nlm.nih.gov/snp)

Maybe you can ask the opposite question; what are the bounds of of a functional human being. https://gnomad.broadinstitute.org/ GnomAD is a aggregation of healthy human genetic sequences which was primarily built on the aggregated control groups of many genetic sequencing studies. There are studies of this data analysing the co-occurrence of variants in gnomAD which may help.

Maybe something like this? https://promethease.com/ Clinvar for variants that might be of clinical relevance. https://gnomad.broadinstitute.org/ for allele frequencies & some info about variants.

You could look at aggregation databases such as gnomad https://gnomad.broadinstitute.org/ anything with a frequency incompatible with the disease is likely non pathogenic

Broad Institute of MIT and Harvard | Cambridge, MA | Frontend Software Engineer | REMOTE or HYBRID (New England area)

We are hiring a frontend developer to help lead the next phase of the gnomAD browser, a web application for displaying the world's largest collection of human genome/exome sequences. https://gnomad.broadinstitute.org. Looking for applicants who are excited about data visualization and designing complex interfaces for scientific research.

Apply here: http://broad.io/cq7dw8

Broad Institute of MIT and Harvard | New England | Software Engineer | REMOTE/HYBRID

Our team is focused on building the tools necessary to visualize and interpret massive data sets of human genetic variation and functional genomic information. We have developed gnomAD (https://gnomad.broadinstitute.org), the world’s largest public reference dataset of human exomes and genomes. gnomAD has become one of the most widely used resources in the field, and is now the default reference database for virtually all clinical interpretation pipelines, as well as a standard analysis resource for a wide variety of genetic and biological studies. We estimate gnomAD has contributed to the clinical diagnosis of over 2 million patients with genetic disorders.

Your role will be to maintain the gnomAD browser, our open source web application for exploring gnomAD and related datasets, and develop new scientific functionality as we continue to grow to over 1 million human samples. You will work with a team of software engineers, computational biologists and clinical and research users to develop new features and visualizations that incorporate user feedback. Software engineering skills and an interest in user interface design and data visualization are key. Basic familiarity with genomics and DNA sequencing data is preferred, but not required. Most importantly, the ideal candidate will have enthusiasm for playing a critical role in a team-oriented project and learning new domains.

Minimum Requirements

If you're talking about humans, start with gnomAD: https://gnomad.broadinstitute.org/

For the web based part, in terms of integration with ROS RobotWebTools (especially with RoslibJS) and rosbridge cover already a lot, so maybe you may want to first check what's available there. Webviz is also a great web based tools with many components for visualisation.

Hey HN, one of the creators here! I made it at Cruise because it was super painful to develop https://webviz.io with manual memory management (lots of ArrayBuffers), WebWorkers, etc. I thought that there must be a better way.

Very curious to hear stories from other folks building intensive stuff in the browser. How are you dealing with performance issues in Javascript? Have you tried using Rust or C++ with WebAssembly for parts of your apps? How did you make 2d/3d rendering faster? Would you want to use something like Zaplib?

Webviz is a great tool. Just drag the .bag file onto the browser window and you can start viewing the data.

Webviz is actually open source for the most part. https://webviz.io

U can try https://webviz.io/ or https://foxglove.dev/

Cruise | Software Engineer | San Francisco, Seattle, or REMOTE | VISA acceptable | https://www.getcruise.com

Cruise is building the world’s most advanced, self-driving vehicles to safely connect people to the places, things, and experiences they care about. We believe self-driving vehicles will help save lives, reshape cities, give back time in transit, and restore freedom of movement for many.

I'm an engineering manager hiring specifically for the Webviz (http://webviz.io/) team. I'm looking for frontend engineers who want to make fast, beautiful browser-based visualizations of the car using WebGL, WASM and Javascript.

Much of the work that we do on this team is open-sourced (check out the code at https://github.com/cruise-automation/webviz). Cruise vehicles produce mountains of data; we have to visualize it in dozens of different ways at a high frame rate. We recently built a Javascript object proxy that wraps all of our input binary data in an object-like interface that only parses data on access, so that we can limit garbage collection pressure and improve our frame rate. If this kind of project sounds interesting, you might enjoy working on Webviz!

Reach out directly to me if you're interested in the above (open to associate/senior/staff levels), or if you have any questions about Cruise.

PS - for those of you who have seen or used Webviz, Foxglove may look familiar. Some of our team previously worked on Webviz at Cruise, and we reused much of their code, although it has been heavily refactored, several new features added, and we have more coming soon.