gnomad-browser VS threatbus

try one of these: GnomAD (https://gnomad.broadinstitute.org/) 1000 Genomes (http://browser.1000genomes.org) dbSNP (http://www.ncbi.nlm.nih.gov/snp)

Maybe you can ask the opposite question; what are the bounds of of a functional human being. https://gnomad.broadinstitute.org/ GnomAD is a aggregation of healthy human genetic sequences which was primarily built on the aggregated control groups of many genetic sequencing studies. There are studies of this data analysing the co-occurrence of variants in gnomAD which may help.

Maybe something like this? https://promethease.com/ Clinvar for variants that might be of clinical relevance. https://gnomad.broadinstitute.org/ for allele frequencies & some info about variants.

You could look at aggregation databases such as gnomad https://gnomad.broadinstitute.org/ anything with a frequency incompatible with the disease is likely non pathogenic

Broad Institute of MIT and Harvard | Cambridge, MA | Frontend Software Engineer | REMOTE or HYBRID (New England area)

We are hiring a frontend developer to help lead the next phase of the gnomAD browser, a web application for displaying the world's largest collection of human genome/exome sequences. https://gnomad.broadinstitute.org. Looking for applicants who are excited about data visualization and designing complex interfaces for scientific research.

Apply here: http://broad.io/cq7dw8

Broad Institute of MIT and Harvard | New England | Software Engineer | REMOTE/HYBRID

Our team is focused on building the tools necessary to visualize and interpret massive data sets of human genetic variation and functional genomic information. We have developed gnomAD (https://gnomad.broadinstitute.org), the world’s largest public reference dataset of human exomes and genomes. gnomAD has become one of the most widely used resources in the field, and is now the default reference database for virtually all clinical interpretation pipelines, as well as a standard analysis resource for a wide variety of genetic and biological studies. We estimate gnomAD has contributed to the clinical diagnosis of over 2 million patients with genetic disorders.

Your role will be to maintain the gnomAD browser, our open source web application for exploring gnomAD and related datasets, and develop new scientific functionality as we continue to grow to over 1 million human samples. You will work with a team of software engineers, computational biologists and clinical and research users to develop new features and visualizations that incorporate user feedback. Software engineering skills and an interest in user interface design and data visualization are key. Basic familiarity with genomics and DNA sequencing data is preferred, but not required. Most importantly, the ideal candidate will have enthusiasm for playing a critical role in a team-oriented project and learning new domains.

Minimum Requirements

If you're talking about humans, start with gnomAD: https://gnomad.broadinstitute.org/

Tenzir | C++, ReasonML, Rust, Python | Hamburg, Germany or Remote (EU timezones) | Open-source | Full-time | https://tenzir.com

Tenzir is an early-stage startup that builds a next generation data-plane for modern Security Operations Centers. It is our mission to help defenders pull ahead by integrating widely used open source tools and building solutions that reduce the time to detect attacks and help with post-mortem investigations. To that end, we develop the high-performance C++ database [VAST](https://github.com/tenzir/vast) with a ReasonML-based frontend that is served by a Rust API. We also develop [Threat Bus](https://github.com/tenzir/threatbus), a dissemination layer for threat intelligence, which orchestrates detection and response products in a publish/subscribe architecture.

We're currently hiring for

Tenzir | Hamburg, Germany| DevOps Platform Engineer | FULL-TIME | REMOTE | €70-80k | https://tenzir.com

Tenzir is seeking an experienced and passionate DevOps / Platform engineer who enjoys bringing open-core security technology into production deployment shape. We cultivate a UNIX-centric mindset: security operators use our high-performance C++ database VAST (https://github.com/tenzir/vast) to hunt in telemetry data, either via the CLI or our ReasonML-based frontend getting its data through a Rust API.

We also develop Threat Bus (https://github.com/tenzir/threatbus), a messaging layer for federating security content.

=== Role & Responsibilities ===

- Improve our CI/CD pipelines for continuous releases with GitHub Actions to build projects of different languages on various platforms and to automate unit and integration testing.

- Automate continuous deployment strategies in different environments, for our own staging and production clusters, but also on-prem (appliances) or with different cloud providers.

- Implement a reliable backend infrastructure for appliance and fleet management, configuration management and multi-layer VPNs.

- Write integrations with other tools from the (security) ecosystem to support a wider range of data formats.

- Be responsible for entire infrastructure segments, from whiteboard design to implementation and automation for production systems.

=== Interview Process ===

1. Fill out the application form at https://tenzir.com/career/devops-platform-engineer/

2. Phone call to get to know each other and identify potential roadblocks (30min)

3. Technical interview(s) (1-2h)

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If you are interested in cutting-edge C++ freelance work, or look for a local sysadmin position, please reach out directly to us at [email protected].

Tenzir | DevOps Platform Engineer | FULL-TIME | €70k | Hamburg, Germany | http://tenzir.com

Tenzir is seeking an experienced and passionate DevOps / Platform engineer who enjoys bringing open-core security technology into production deployment shape. We cultivate a UNIX-centric mindset: security operators use our high-performance C++ database VAST (https://github.com/tenzir/vast) to hunt in telemetry data, either via the CLI our our ReasonML-based frontend getting its data through a Rust API. We also develop Threat Bus (https://github.com/tenzir/threatbus), a dissemination layer for threat intelligence, which orchestrates detection and response.

=== Role & Responsibilities ===

As a key contributor to our infrastructure, you will improve and automate critical processes for building, packaging, and deploying our technology in test and production environments. Concretely:

Tenzir is seeking an experienced and passionate DevOps / Platform engineer who enjoys bringing open-core security technology into production deployment shape. We cultivate a UNIX-centric mindset: security operators use our high-performance C++ database VAST to hunt in telemetry data, either via the CLI our our ReasonML-based frontend getting its data through a Rust API. We also develop Threat Bus, a dissemination layer for threat intelligence, which orchestrates detection and response.