bonito VS logseq

There is a technology called Nanopore. I’ve never used it myself but the concept was to be able to sequence samples of nucleic acid out in the field. A quick pubmed search indicated that it can detect miRNA, but maybe with some modifications. https://nanoporetech.com Best of luck with it!

> An unpopular opinion: there are too many other logos that look like the original logo

There are also too many logos that look like the new logo. The first blue circle logos that spring to mind are Blue Circle Cement/Tarmac/Lafarge [1] and Oxford Nanopore [2].

[1]: https://en.wikipedia.org/wiki/Tarmac_(company)

[2]: https://nanoporetech.com/

Oxford Nanopore Technologies (https://nanoporetech.com/) | Front end developer | Full-time | Oxford | Remote (UK)

Oxford Nanopore Technologies is headquartered at the Oxford Science Park outside Oxford, UK, with satellite offices and commercial presence in many global locations across the US, APAC and Europe. Our DNA/RNA sequencing platform is the only technology that offers real-time analysis (for rapid insights), in fully scalable formats from pocket to population scale. Our goal is to enable the analysis of any living thing, by anyone, anywhere.

Tech stack: Electron, Stencil, React, Typescript, RxJS, GRPC

For more details, please email: [email protected]

Ok this isn't really my area but I know that there are labs/companies performing these types of electrical current disturbance measurements of membrane-type proteins for both DNA sequencing (https://nanoporetech.com/) and protein sequencing (https://www.nature.com/articles/s41587-019-0401-y).

Now nanopore sequencing is solid state and gets much longer reads. https://nanoporetech.com/ and https://en.wikipedia.org/wiki/Nanopore_sequencing

Also best of luck with the basecaller, I will say that the latest guppy versions are very good, both in terms of accuracy and speed, as they are GPU accelerated and the best I've seen in accuracy. You may also be interested in Bonito, a tool to generate your own GPU basecalling model or tweak existing models to your data. https://github.com/nanoporetech/bonito.

Logseq support via our Logseq Plugin

Sorry, but _what exactly_ «it seems to do» from your point of view?

My «second brain» now is almost 300Mb of text, pictures, sound files, PDF and other stuff. As I already mentioned, it contains tables, mathematical formulae, sheet music, cross-references, code samples, UML diagrams and graphs in Graphviz format. It is versioned, indexed by local search engine, analyzed by AI assistant and shared between many computers and mobile devices. And (last but not least) it works: it allows me to solve my tasks way more faster than with the assistant of external, non-personalized tools (like ChatGPT, StackExchange or Google).

I know no tools for all this tasks except org-mode. Well, maybe Evernote in the 2010-s was something similar — but with less features, with more bugs and with worse interface.

Personal note-taking _is_ a complex task per se (well, at least for someone like typical HN visitor). I've seen many note-taking tools, that were ridiculously featureless, stupid and inconvenient because they were _not_ complex enough.

> Sure if one wants to do emacs-gardening it is fine.

1)You can use org-mode outside Emacs. See for example Logseq (https://logseq.com/), organice (https://organice.200ok.ch/) or EasyOrg.

2)Org-mode works in Emacs out of the box, you don't need any «emacs-gardening» to use org-mode.

3)The term «Emacs-gardening» itself sound a bit like hate-speech for me. The complexity of Emacs customization is overrated, mostly due to opinions of people who never used Emacs or used it in the previous millennium.

Obsidian is great.

For those looking for an open source alternative (or don't want to pay the Obsidian fees for professional usage) check out Logseq: https://logseq.com/

For an opensource alternative to Obsidian checkout Logseq (1). I spent a while thinking obsidian was opensource out of my own ignorance and was disappointed when I learned it was not.

1: https://logseq.com/

I use logseq to keep journal of my daily work.

While Emacs and Org mode can certainly be used for this (and, when they can't, you can always inject little python/js scripts in your emacs config to take care of specific things), I'd also recommend you take a look at Logseq.