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nmigen
A refreshed Python toolbox for building complex digital hardware. See https://gitlab.com/nmigen/nmigen
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InfluxDB
Power Real-Time Data Analytics at Scale. Get real-time insights from all types of time series data with InfluxDB. Ingest, query, and analyze billions of data points in real-time with unbounded cardinality.
You can either decide to learn VHDL/Verilog, or use something like nmigen. I recommend learning either Verilog or VHDL anyway, so you can at least read and understand existing designs, but I personally use nmigen.
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.