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I'll use my XFCP project to interface with the FPGA from Python via a USB serial chip. This provides access to the I2C bus on the board, for configuring the PLL chips and interfacing with the QSFP28 optical transceivers. Additionally, it connects to the dynamic reconfiguration ports (DRP) on the GTY transceivers, and I'll use that for performing BER measurements at 25 Gbps through a handful of QSFP28 cables and optical modules. It looks like I might also have to do some fine-tuning of some of the analog parameters on the transceivers (namely pre-emphasis).