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InfluxDB
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Find a remake of the game ported to a modern engine. https://www.dxx-rebirth.com/ appears to be a port of Descent 1 and 2 to the Source engine. It won't help with you running the 3DFX version, of course, but this might actually be better?
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.