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Top 23 Python Research Projects
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khoj
Your AI second brain. Self-hostable. Get answers from the web or your docs. Build custom agents, schedule automations, do deep research. Turn any online or local LLM into your personal, autonomous AI (gpt, claude, gemini, llama, qwen, mistral). Get started - free.
GitHub https://github.com/khoj-ai/khoj GitHub Star 12.4k GitHub Fork 627 GitHub Issue 64 GitHub Pull Request 3 GitHub Contributor 35 Open Source License AGPL-3.0 Official Website https://khoj.dev/ Documentation https://docs.khoj.dev/
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InfluxDB
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qlib
Qlib is an AI-oriented quantitative investment platform that aims to realize the potential, empower research, and create value using AI technologies in quantitative investment, from exploring ideas to implementing productions. Qlib supports diverse machine learning modeling paradigms. including supervised learning, market dynamics modeling, and RL.
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RD-Agent
Research and development (R&D) is crucial for the enhancement of industrial productivity, especially in the AI era, where the core aspects of R&D are mainly focused on data and models. We are committed to automating these high-value generic R&D processes through our open source R&D automation tool R&D-Agent, which lets AI drive data-driven AI.
Project mention: RD-Agent: LLM-based autonomous evolving agents for industrial data-driven R&D | news.ycombinator.com | 2024-09-25 -
mlfinlab
MlFinLab helps portfolio managers and traders who want to leverage the power of machine learning by providing reproducible, interpretable, and easy to use tools.
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SaaSHub
SaaSHub - Software Alternatives and Reviews. SaaSHub helps you find the best software and product alternatives
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habitat-lab
A modular high-level library to train embodied AI agents across a variety of tasks and environments.
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diamond
DIAMOND (DIffusion As a Model Of eNvironment Dreams) is a reinforcement learning agent trained in a diffusion world model. NeurIPS 2024 Spotlight.
I think https://diamond-wm.github.io is a reasonable place to start (they have public world-model training code, and people have successfully adapted their codebase to other games e.g. https://derewah.dev/projects/ai-mariokart). Most modern world models are essentially image generators with additional inputs (past-frames + controls) added on, so understanding how Diffusion/IADB/Flow Matching work would definitely help.
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PyGame-Learning-Environment
PyGame Learning Environment (PLE) -- Reinforcement Learning Environment in Python.
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Mava
š¦ A research-friendly codebase for fast experimentation of multi-agent reinforcement learning in JAX
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tldw
tl/dw (Too Long, Didn't Watch): Your Personal Research Multi-Tool - a naive attempt at 'A Young Lady's Illustrated Primer' (Open Source NotebookLM)
Project mention: Show HN: Morphik ā Open-source RAG that understands PDF images, runs locally | news.ycombinator.com | 2025-04-22Hey yes, Iām building exactly that.
https://github.com/rmusser01/tldw
I first built a POC in gradio and am now rebuilding it as a FastAPI app. The media processing endpoints work but Iām still tweaking media ingestion to allow for syncing to clients(idea is to allow for client-first design).
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pybossa
PYBOSSA is the ultimate crowdsourcing framework (aka microtasking) to analyze or enrich data that can't be processed by machines alone.
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Project mention: Promptic ā the "requests" of LLM app development | news.ycombinator.com | 2024-11-26
Thanks for the kind words! I'm a fan of magentic :) One of the projects I've built with promptic is https://pdf-to-podcast.com
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SaaSHub
SaaSHub - Software Alternatives and Reviews. SaaSHub helps you find the best software and product alternatives
NOTE:
The open source projects on this list are ordered by number of github stars.
The number of mentions indicates repo mentiontions in the last 12 Months or
since we started tracking (Dec 2020).
Python Research discussion
Python Research related posts
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GitHub ā ByteDance/UI-Tars
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Datahawk ā Text data browser for NLP, LLM researchers and developers
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Papers for Software Engineers
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A curated list of papers for Software Engineers
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VectorChord: Store 400k Vectors for $1 in PostgreSQL
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Promptic ā the "requests" of LLM app development
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Show HN: PDF to Podcast ā Convert Any PDF into a Podcast Episode
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A note from our sponsor - InfluxDB
www.influxdata.com | 19 May 2025
Index
What are some of the best open-source Research projects in Python? This list will help you:
| # | Project | Stars |
|---|---|---|
| 1 | khoj | 30,051 |
| 2 | qlib | 19,206 |
| 3 | UI-TARS | 5,950 |
| 4 | software-papers | 5,860 |
| 5 | RD-Agent | 4,348 |
| 6 | mlfinlab | 4,165 |
| 7 | acme | 3,676 |
| 8 | scenic | 3,538 |
| 9 | catalyst | 3,336 |
| 10 | lingvo | 2,839 |
| 11 | habitat-lab | 2,341 |
| 12 | diamond | 1,817 |
| 13 | Papers-in-100-Lines-of-Code | 1,505 |
| 14 | music_source_separation | 1,329 |
| 15 | yacs | 1,311 |
| 16 | SALMONN | 1,227 |
| 17 | PyGame-Learning-Environment | 1,034 |
| 18 | dreamerv2 | 929 |
| 19 | iris | 839 |
| 20 | Mava | 794 |
| 21 | tldw | 790 |
| 22 | pybossa | 754 |
| 23 | pdf-to-podcast | 751 |
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