gnomad-browser
rotki
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gnomad-browser | rotki | |
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15 | 119 | |
78 | 2,608 | |
- | 3.0% | |
9.7 | 9.9 | |
3 days ago | 4 days ago | |
TypeScript | Python | |
MIT License | GNU Affero General Public License v3.0 |
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gnomad-browser
- All identified polymorphisms in a given gene, how to find?
- AskScience AMA Series: We're human genetics researchers here to discuss connections between people in different geographical regions. Ask us anything!
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Converting 23&Me raw data into a format usable by Admixtools 2
try one of these: GnomAD (https://gnomad.broadinstitute.org/) 1000 Genomes (http://browser.1000genomes.org) dbSNP (http://www.ncbi.nlm.nih.gov/snp)
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What is the maximum number of human?
Maybe you can ask the opposite question; what are the bounds of of a functional human being. https://gnomad.broadinstitute.org/ GnomAD is a aggregation of healthy human genetic sequences which was primarily built on the aggregated control groups of many genetic sequencing studies. There are studies of this data analysing the co-occurrence of variants in gnomAD which may help.
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Insights from personal sequencing data I can explore.
Maybe something like this? https://promethease.com/ Clinvar for variants that might be of clinical relevance. https://gnomad.broadinstitute.org/ for allele frequencies & some info about variants.
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What are some non-pathogenic alleles of the SNCA gene, or how do I find them?
You could look at aggregation databases such as gnomad https://gnomad.broadinstitute.org/ anything with a frequency incompatible with the disease is likely non pathogenic
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Ask HN: Who is hiring? (March 2022)
Broad Institute of MIT and Harvard | Cambridge, MA | Frontend Software Engineer | REMOTE or HYBRID (New England area)
We are hiring a frontend developer to help lead the next phase of the gnomAD browser, a web application for displaying the world's largest collection of human genome/exome sequences. https://gnomad.broadinstitute.org. Looking for applicants who are excited about data visualization and designing complex interfaces for scientific research.
Apply here: http://broad.io/cq7dw8
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Ask HN: Who is hiring? (February 2022)
Broad Institute of MIT and Harvard | New England | Software Engineer | REMOTE/HYBRID
Our team is focused on building the tools necessary to visualize and interpret massive data sets of human genetic variation and functional genomic information. We have developed gnomAD (https://gnomad.broadinstitute.org), the world’s largest public reference dataset of human exomes and genomes. gnomAD has become one of the most widely used resources in the field, and is now the default reference database for virtually all clinical interpretation pipelines, as well as a standard analysis resource for a wide variety of genetic and biological studies. We estimate gnomAD has contributed to the clinical diagnosis of over 2 million patients with genetic disorders.
Your role will be to maintain the gnomAD browser, our open source web application for exploring gnomAD and related datasets, and develop new scientific functionality as we continue to grow to over 1 million human samples. You will work with a team of software engineers, computational biologists and clinical and research users to develop new features and visualizations that incorporate user feedback. Software engineering skills and an interest in user interface design and data visualization are key. Basic familiarity with genomics and DNA sequencing data is preferred, but not required. Most importantly, the ideal candidate will have enthusiasm for playing a critical role in a team-oriented project and learning new domains.
Minimum Requirements
- Ask HN: How to be my own genetic disease researcher for my partner?
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How to check if a discovered mutation is novel or was discovered before ?
If you're talking about humans, start with gnomAD: https://gnomad.broadinstitute.org/
rotki
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Does anyone know of a "zapper" like portfolio tracker that automatically calculates Profit/Loss?
That already exists: https://rotki.com/
- How can I calculate how much crypto I've received on my crypto address?
- The best DeFI portfolio tracker?
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Best Crypto Tools: The Ultimate Checklist for 2023
-Rotki: https://rotki.com/ Management
- Zen Ledger will file your crypto taxes for $3500.
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Portfolio app recommendations
Try rotki
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Daily General Discussion - March 30, 2023
Pretty sure https://rotki.com folks would add it soon.
- Crypto might be user friendly when it’s easy to do taxes for it
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Where can I teach people programming for free?
If you’re keen, I’m trying / learning to contribute to a Python project: https://github.com/rotki/rotki I’ve been in dad duties for the past 10~ish years so there’re a lot to catch up on.
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Looking for a better portfolio tracker
Check out Rotki. It's open source, keeps data local, and it comes with a bunch of features for free. Not everything is integrated yet as it is still under active development, but it's the best portfolio tracker out there that I know of. And it's only $12/mo for the paid features, which goes to supporting the indie dev team lead by Ethereum OG Lefteris Karapetsas.
What are some alternatives?
webviz - web-based visualization libraries
rocketpool - Decentralised Ethereum Liquid Staking Protocol.
haystack - :mag: LLM orchestration framework to build customizable, production-ready LLM applications. Connect components (models, vector DBs, file converters) to pipelines or agents that can interact with your data. With advanced retrieval methods, it's best suited for building RAG, question answering, semantic search or conversational agent chatbots.
beancount - Beancount: Double-Entry Accounting from Text Files.
metamask-extension - :globe_with_meridians: :electric_plug: The MetaMask browser extension enables browsing Ethereum blockchain enabled websites
BittyTax - Crypto-currency tax calculator with support for all popular wallets, exchanges, explorers and migration from other crypto tax platforms
aioli - Framework for building fast genomics web tools with WebAssembly and WebWorkers
lowdefy - The config web stack for business apps - build internal tools, client portals, web apps, admin panels, dashboards, web sites, and CRUD apps with YAML or JSON.
Baserow - Open source no-code database and Airtable alternative. Create your own online database without technical experience. Performant with high volumes of data, can be self hosted and supports plugins
MyEtherWallet - MyEtherWallet (our friends call us MEW) is a free, client-side interface helping you interact with the Ethereum blockchain.
FrameworkBenchmarks - Source for the TechEmpower Framework Benchmarks project
grouparoo - 🦘 The Grouparoo Monorepo - open source customer data sync framework