InfluxDB 3 OSS is now GA. Transform, enrich, and act on time series data directly in the database. Automate critical tasks and eliminate the need to move data externally. Download now. Learn more →
Top 23 Python Blockchain Projects
-
chia-blockchain
Chia blockchain python implementation (full node, farmer, harvester, timelord, and wallet)
-
InfluxDB
InfluxDB – Built for High-Performance Time Series Workloads. InfluxDB 3 OSS is now GA. Transform, enrich, and act on time series data directly in the database. Automate critical tasks and eliminate the need to move data externally. Download now.
-
lbry-sdk
The LBRY SDK for building decentralized, censorship resistant, monetized digital content apps.
-
mythril
Mythril is a symbolic-execution-based securty analysis tool for EVM bytecode. It detects security vulnerabilities in smart contracts built for Ethereum and other EVM-compatible blockchains.
-
-
rotki
A portfolio tracking, analytics, accounting and management application that protects your privacy
-
-
SimpleCoin
Just a really simple, insecure and incomplete implementation of a blockchain for a cryptocurrency made in Python as educational material. In other words, a simple Bitcoin clone. (by cosme12)
-
SaaSHub
SaaSHub - Software Alternatives and Reviews. SaaSHub helps you find the best software and product alternatives
-
-
-
-
-
-
-
defi
Tools for use in DeFi. Impermanent Loss calculations, staking and farming strategies, coingecko and pancakeswap API queries, liquidity pools and more (by gauss314)
-
-
-
-
ecdsa-private-key-recovery
A simple library to recover the private key of ECDSA and DSA signatures sharing the same nonce k and therefore having identical signature parameter r
-
-
-
-
machinaris
An easy-to-use WebUI for crypto plotting and farming. Offers Bladebit, Gigahorse, MadMax, Chiadog and Plotman in a Docker container. Supports Chia, MMX, Chives, Flax, and HDDCoin among others.
-
nft-generator-py
This tool allows users to generate sets of unique images and metadata using weighted layer collections.
-
SaaSHub
SaaSHub - Software Alternatives and Reviews. SaaSHub helps you find the best software and product alternatives
NOTE:
The open source projects on this list are ordered by number of github stars.
The number of mentions indicates repo mentiontions in the last 12 Months or
since we started tracking (Dec 2020).
Python Blockchain discussion
Python Blockchain related posts
-
Self-hosting your own media considered harmful according to YouTube
-
Run Sepolia node
-
Account Abstraction Progress, Ethereum’s L2 Roadmap Insight, RISC-V Execution Layer Proposal, Pectra Blob-Scaling
-
Preview of SERENDIPITY: selfhosted AI, custom personas, STT, TTS, RAG, tools [video]
-
Show HN: Preview of Serendipity – A Collective of AI Agents by Valyrian Tech [video]
-
Top YouTube Alternatives to Watch in 2024 📹
-
A Better Mastodon Client
-
A note from our sponsor - InfluxDB
www.influxdata.com | 24 Jun 2025
Index
What are some of the best open-source Blockchain projects in Python? This list will help you:
| # | Project | Stars |
|---|---|---|
| 1 | chia-blockchain | 10,855 |
| 2 | lbry-sdk | 7,210 |
| 3 | mythril | 4,043 |
| 4 | manticore | 3,767 |
| 5 | rotki | 3,146 |
| 6 | raiden | 1,840 |
| 7 | SimpleCoin | 1,791 |
| 8 | smart-contract-sanctuary | 1,569 |
| 9 | solana-py | 1,367 |
| 10 | smart-contracts | 1,339 |
| 11 | bittensor | 1,168 |
| 12 | bitcoin-abe | 978 |
| 13 | 0xDeCA10B | 581 |
| 14 | defi | 577 |
| 15 | yearn-vaults | 534 |
| 16 | pool-reference | 435 |
| 17 | QRL | 434 |
| 18 | ecdsa-private-key-recovery | 416 |
| 19 | fabric-sdk-py | 411 |
| 20 | sepolia | 387 |
| 21 | py-stellar-base | 366 |
| 22 | machinaris | 343 |
| 23 | nft-generator-py | 310 |
Sponsored
InfluxDB – Built for High-Performance Time Series Workloads
InfluxDB 3 OSS is now GA. Transform, enrich, and act on time series data directly in the database. Automate critical tasks and eliminate the need to move data externally. Download now.
www.influxdata.com