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Top 23 Python Blockchain Projects
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chia-blockchain
Chia blockchain python implementation (full node, farmer, harvester, timelord, and wallet)
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InfluxDB
InfluxDB β Built for High-Performance Time Series Workloads. InfluxDB 3 OSS is now GA. Transform, enrich, and act on time series data directly in the database. Automate critical tasks and eliminate the need to move data externally. Download now.
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lbry-sdk
The LBRY SDK for building decentralized, censorship resistant, monetized digital content apps.
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mythril
Mythril is a symbolic-execution-based securty analysis tool for EVM bytecode. It detects security vulnerabilities in smart contracts built for Ethereum and other EVM-compatible blockchains.
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rotki
A portfolio tracking, analytics, accounting and management application that protects your privacy
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SimpleCoin
Just a really simple, insecure and incomplete implementation of a blockchain for a cryptocurrency made in Python as educational material. In other words, a simple Bitcoin clone. (by cosme12)
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SaaSHub
SaaSHub - Software Alternatives and Reviews. SaaSHub helps you find the best software and product alternatives
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defi
Tools for use in DeFi. Impermanent Loss calculations, staking and farming strategies, coingecko and pancakeswap API queries, liquidity pools and more (by gauss314)
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ecdsa-private-key-recovery
A simple library to recover the private key of ECDSA and DSA signatures sharing the same nonce k and therefore having identical signature parameter r
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machinaris
An easy-to-use WebUI for crypto plotting and farming. Offers Bladebit, Gigahorse, MadMax, Chiadog and Plotman in a Docker container. Supports Chia, MMX, Chives, Flax, and HDDCoin among others.
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nft-generator-py
This tool allows users to generate sets of unique images and metadata using weighted layer collections.
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SaaSHub
SaaSHub - Software Alternatives and Reviews. SaaSHub helps you find the best software and product alternatives
Python Blockchain discussion
Python Blockchain related posts
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Self-hosting your own media considered harmful according to YouTube
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Run Sepolia node
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Account Abstraction Progress, Ethereumβs L2 Roadmap Insight, RISC-V Execution Layer Proposal, Pectra Blob-Scaling
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Preview of SERENDIPITY: selfhosted AI, custom personas, STT, TTS, RAG, tools [video]
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Show HN: Preview of Serendipity β A Collective of AI Agents by Valyrian Tech [video]
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Top YouTube Alternatives to Watch in 2024 πΉ
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A Better Mastodon Client
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A note from our sponsor - InfluxDB
www.influxdata.com | 24 Jun 2025
Index
What are some of the best open-source Blockchain projects in Python? This list will help you:
# | Project | Stars |
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1 | chia-blockchain | 10,855 |
2 | lbry-sdk | 7,210 |
3 | mythril | 4,043 |
4 | manticore | 3,767 |
5 | rotki | 3,146 |
6 | raiden | 1,840 |
7 | SimpleCoin | 1,791 |
8 | smart-contract-sanctuary | 1,569 |
9 | solana-py | 1,367 |
10 | smart-contracts | 1,339 |
11 | bittensor | 1,168 |
12 | bitcoin-abe | 978 |
13 | 0xDeCA10B | 581 |
14 | defi | 577 |
15 | yearn-vaults | 534 |
16 | pool-reference | 435 |
17 | QRL | 434 |
18 | ecdsa-private-key-recovery | 416 |
19 | fabric-sdk-py | 411 |
20 | sepolia | 387 |
21 | py-stellar-base | 366 |
22 | machinaris | 343 |
23 | nft-generator-py | 310 |