gnomad-browser
openpilot
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gnomad-browser | openpilot | |
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15 | 839 | |
78 | 47,461 | |
- | 1.6% | |
9.7 | 10.0 | |
3 days ago | 5 days ago | |
TypeScript | Python | |
MIT License | MIT License |
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Activity is a relative number indicating how actively a project is being developed. Recent commits have higher weight than older ones.
For example, an activity of 9.0 indicates that a project is amongst the top 10% of the most actively developed projects that we are tracking.
gnomad-browser
- All identified polymorphisms in a given gene, how to find?
- AskScience AMA Series: We're human genetics researchers here to discuss connections between people in different geographical regions. Ask us anything!
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Converting 23&Me raw data into a format usable by Admixtools 2
try one of these: GnomAD (https://gnomad.broadinstitute.org/) 1000 Genomes (http://browser.1000genomes.org) dbSNP (http://www.ncbi.nlm.nih.gov/snp)
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What is the maximum number of human?
Maybe you can ask the opposite question; what are the bounds of of a functional human being. https://gnomad.broadinstitute.org/ GnomAD is a aggregation of healthy human genetic sequences which was primarily built on the aggregated control groups of many genetic sequencing studies. There are studies of this data analysing the co-occurrence of variants in gnomAD which may help.
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Insights from personal sequencing data I can explore.
Maybe something like this? https://promethease.com/ Clinvar for variants that might be of clinical relevance. https://gnomad.broadinstitute.org/ for allele frequencies & some info about variants.
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What are some non-pathogenic alleles of the SNCA gene, or how do I find them?
You could look at aggregation databases such as gnomad https://gnomad.broadinstitute.org/ anything with a frequency incompatible with the disease is likely non pathogenic
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Ask HN: Who is hiring? (March 2022)
Broad Institute of MIT and Harvard | Cambridge, MA | Frontend Software Engineer | REMOTE or HYBRID (New England area)
We are hiring a frontend developer to help lead the next phase of the gnomAD browser, a web application for displaying the world's largest collection of human genome/exome sequences. https://gnomad.broadinstitute.org. Looking for applicants who are excited about data visualization and designing complex interfaces for scientific research.
Apply here: http://broad.io/cq7dw8
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Ask HN: Who is hiring? (February 2022)
Broad Institute of MIT and Harvard | New England | Software Engineer | REMOTE/HYBRID
Our team is focused on building the tools necessary to visualize and interpret massive data sets of human genetic variation and functional genomic information. We have developed gnomAD (https://gnomad.broadinstitute.org), the world’s largest public reference dataset of human exomes and genomes. gnomAD has become one of the most widely used resources in the field, and is now the default reference database for virtually all clinical interpretation pipelines, as well as a standard analysis resource for a wide variety of genetic and biological studies. We estimate gnomAD has contributed to the clinical diagnosis of over 2 million patients with genetic disorders.
Your role will be to maintain the gnomAD browser, our open source web application for exploring gnomAD and related datasets, and develop new scientific functionality as we continue to grow to over 1 million human samples. You will work with a team of software engineers, computational biologists and clinical and research users to develop new features and visualizations that incorporate user feedback. Software engineering skills and an interest in user interface design and data visualization are key. Basic familiarity with genomics and DNA sequencing data is preferred, but not required. Most importantly, the ideal candidate will have enthusiasm for playing a critical role in a team-oriented project and learning new domains.
Minimum Requirements
- Ask HN: How to be my own genetic disease researcher for my partner?
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How to check if a discovered mutation is novel or was discovered before ?
If you're talking about humans, start with gnomAD: https://gnomad.broadinstitute.org/
openpilot
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Tinygrad: Hacked 4090 driver to enable P2P
Yes, but he spent several years in self-driving cars (https://comma.ai), which while interesting is also a space that a lot of players are in, so it's not the same as seeing him back to doing stuff that's a little more out there, especially as pertains to IP.
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Imitation Learning
We have a product for sale: https://comma.ai
We raised $18.1M and have made $28M in lifetime revenue to date.
Where are you getting your narrative?
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Driverless cars immune from traffic tickets in California under current laws
What about comma? https://comma.ai/ Seems like our old friend geohot built exactly what you want.
Positive HN discussion: https://news.ycombinator.com/item?id=36927971
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No USS?
The issue was that the front camera on the windshield couldn’t see under the hood. You misunderstand how easy it is to solve for depth and distance with AI without requiring stereo cameras. Read https://github.com/commaai/openpilot
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What car should I get for Seattle city and some ski/hike driving? Or not get a car at all?
Nice to have: I want to get a self-driving add-on that supports some cars better than others. Not a must but high up on my nice-to-have list.
- I need some help understanding video uploads.
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I am nearing the end of my Kona 2020 lease, and I have an appointment at a dealer tomorrow had some questions about leasing an ioniq 6, hopefully someone can help me out.
EDIT: I probably should have added that I currently have the base model of the Kona the lowest model available, and I am looking for a similar thing in the ioniq 6, because my understanding is that it's fully compatible with the comma.ai device and therefore I am not planning on getting the better on board driving system, the Kona that I got unfortunately was not compatible with that device.
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Tesla: Security Vulnerabilities
I wonder how bad this is compared to the competition. https://comma.ai allows you to add self-driving features to a large number of non-Tesla cars so, if we’re including physical firmware hacks as a threat vector, I’d bet tons of alternative cars (new enough Honda Odysseys, Toyota Siennas, etc: probably anything with adaptive cruise control and lane following) have the same sort of potential vulnerability.
- 2024 highlander has Toyota Security Key Now
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Cruise co-founder and CEO Kyle Vogt resigns
Not sure, but from the first article from 4 years ago:
>Last month, we had 1,209 cars drive a little over 1,000,000 miles
Let's say they've had zero growth since then, so 48,000,000 conservatively?
Actually, from their website [1]:
>100+ million miles driven and 10k users.
[1]: https://comma.ai
What are some alternatives?
webviz - web-based visualization libraries
sunnypilot - sunnypilot is a fork of comma.ai's openpilot, an open source driver assistance system. sunnypilot offers the user a unique driving experience for over 290 supported car makes and models with modified behaviors of driving assist engagements. sunnypilot complies with comma.ai's safety rules as accurately as possible.
haystack - :mag: LLM orchestration framework to build customizable, production-ready LLM applications. Connect components (models, vector DBs, file converters) to pipelines or agents that can interact with your data. With advanced retrieval methods, it's best suited for building RAG, question answering, semantic search or conversational agent chatbots.
opendbc - democratize access to car decoder rings
metamask-extension - :globe_with_meridians: :electric_plug: The MetaMask browser extension enables browsing Ethereum blockchain enabled websites
carla - Open-source simulator for autonomous driving research.
aioli - Framework for building fast genomics web tools with WebAssembly and WebWorkers
dragonpilot - dragonpilot - 基於 openpilot 的開源駕駛輔助系統
Baserow - Open source no-code database and Airtable alternative. Create your own online database without technical experience. Performant with high volumes of data, can be self hosted and supports plugins
label-studio - Label Studio is a multi-type data labeling and annotation tool with standardized output format
FrameworkBenchmarks - Source for the TechEmpower Framework Benchmarks project
netron - Visualizer for neural network, deep learning and machine learning models