PyWin32 vs PythonNet

PyWin32

python for windows extensions (by Travis-Sun)

Python for .NET is a package that gives Python programmers nearly seamless integration with the .NET Common Language Runtime (CLR) and provides a powerful application scripting tool for .NET developers. (by pythonnet)

Microsoft Windows Python .NET Mono CLR Pythonnet FFI C# HacktoberFest

Source Code

pythonnet.github.io

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PyWin32		PythonNet
	Project
-	Mentions	37
27	Stars	4,364
-	Growth	1.1%
0.0	Activity	7.0
over 11 years ago	Latest Commit	6 days ago
C++	Language	C#
Python License 2.0	License	MIT License

The number of mentions indicates the total number of mentions that we've tracked plus the number of user suggested alternatives.
Stars - the number of stars that a project has on GitHub. Growth - month over month growth in stars.
Activity is a relative number indicating how actively a project is being developed. Recent commits have higher weight than older ones.
For example, an activity of 9.0 indicates that a project is amongst the top 10% of the most actively developed projects that we are tracking.

PyWin32

Posts with mentions or reviews of PyWin32. We have used some of these posts to build our list of alternatives and similar projects.

We haven't tracked posts mentioning PyWin32 yet.
Tracking mentions began in Dec 2020.

PythonNet

Posts with mentions or reviews of PythonNet. We have used some of these posts to build our list of alternatives and similar projects. The last one was on 2023-10-18.

I modified and hacked away xonsh source code
2 projects | /r/xonsh | 18 Oct 2023
Multi-threaded task processing engine that supports both sync and async execution
1 project | /r/learnpython | 7 Oct 2023

I looked into using .NET as a "backend" and the pythonnet library to bridge the gap, but unfortunately that library does not support async. To properly support it would require some kind of integration with the asyncio event loop APIs or implement the AbstractEventLoop interface and some how make it thread-safe - not even sure that's possible with the API design of asyncio itself.
[WPF, C#] Need ideas on how to automate these operations based on the response I get from python script.
2 projects | /r/dotnet | 9 Jun 2023

If you're running the python within C# using Python.NET, then you're somewhat within-process and there are ways of sending the data across. (Return objects, channel/queues, whatever fits your use case.)
Found this on a job description. Wasn't aware .Net supports Java & Python! .Net core is really coming along.
1 project | /r/programminghumor | 2 Jun 2023

I was going to make a joke about Python .NET core .. but .. apparently it's a real thing.
Announcing .NET 8 Preview 4 - .NET Blog
1 project | /r/csharp | 17 May 2023
Starting Python, confused about cross platform app development. Is IronPython + .NET the only option?
4 projects | /r/learnpython | 26 Apr 2023

I am not set on .NET, but just curious, so thanks for the suggestions. Interesting that it's billed as cross-plaform, but doesn't do it that well. I just searched 'python wrapper for .net' and found PythonNET. Also, it seems yes IronPython is active.
TIA Openness with Docker
2 projects | /r/PLC | 30 Mar 2023

I created a Django based python project that interfaces to TIA Openness to create some Remote IO. To do this I use the pythonnet library. so that I can load the Openness DLL.
Guidance into the unknown...
1 project | /r/learnpython | 3 Mar 2023
mask detection model made with python, need to make predictions with that model in C#
1 project | /r/tensorflow | 23 Feb 2023
Python's “Disappointing” Superpowers
9 projects | news.ycombinator.com | 1 Feb 2023

Any .NET language with https://github.com/pythonnet/pythonnet

What are some alternatives?

When comparing PyWin32 and PythonNet you can also consider the following projects:

WinPython - A free Python-distribution for Windows platform, including prebuilt packages for Scientific Python.

Iron python - Implementation of the Python programming language for .NET Framework; built on top of the Dynamic Language Runtime (DLR).

pyxll-utils

pythonlibs - A Python wrapper for the extremely fast Blosc compression library

CefSharp - .NET (WPF and Windows Forms) bindings for the Chromium Embedded Framework

Open-Shell-Menu - Classic Shell Reborn.

CppSharp - Tools and libraries to glue C/C++ APIs to high-level languages

NuGetForUnity - A NuGet Package Manager for Unity

pinvoke - A library containing all P/Invoke code so you don't have to import it every time. Maintained and updated to support the latest Windows OS.

LegacyWrapper - LegacyWrapper uses a x86 wrapper to call legacy dlls from a 64 bit process (or vice versa).