Tamtools Alternatives
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tamtools reviews and mentions
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We're wasting money by only supporting gzip for raw DNA files
A few years ago I built some tools https://github.com/tf318/tamtools to store alignments against two different reference assemblies in an efficient way (taking advantage of the fact that the majority of each alignment to different assemblies would in fact be the same, just shifted in position).
The intent was to enhance this to store alignments against multiple references as new references are published, and probably to rewrite in Rust or C rather than the initial Python effort.
In retrospect I would be interested to know whether this domain-specific compression effort, with zstd to the resulting "hybrid" alignment, would be more efficient than just letting zstd do its own thing with a full set of individual alignments against the different references.
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tf318/tamtools is an open source project licensed under GNU General Public License v3.0 only which is an OSI approved license.
The primary programming language of tamtools is Python.
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