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https://github.com/lihaoyi/macropy. It's harder to use than Lisp macros though. Besides eval/exec, which allow string metaprogramming, an AST manipulation module is in the standard library, but it's even harder to work with than macropy.
If you want Lisp metaprogramming plus Python ecosystem, check out Hissp
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Hence, a higher number means a more popular project.
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