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Proton is meant to be used with Steam and depends on the Steam runtime, for non-steam games there exists Wine-GE, which backports all the game fixes from Proton-GE into Wine.
Lutris disabled the use of proton by default because it's not designed to use proton the way it's intended. Instead, you should use wine-ge. It has the same patches and lutris will handle enabling dxvk and the rest.
Proton is meant to be used with Steam and depends on the Steam runtime, for non-steam games there exists Wine-GE, which backports all the game fixes from Proton-GE into Wine.