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immunedeconv
A unified interface to immune deconvolution methods (CIBERSORT, EPIC, quanTIseq, TIMER, xCell, MCPcounter) and mouse deconvolution methods
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InfluxDB
Power Real-Time Data Analytics at Scale. Get real-time insights from all types of time series data with InfluxDB. Ingest, query, and analyze billions of data points in real-time with unbounded cardinality.
Check the various methods under https://github.com/icbi-lab/immunedeconv
I would suggest you to try out AutoGeneS. Not necessarily reference-free, but versatile and combines bulk/scRNA-seq data well. You can use the latter to generate the priors for cell proportions. https://github.com/theislab/AutoGeneS https://pubmed.ncbi.nlm.nih.gov/34293324/ HTH
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