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InfluxDB
Power Real-Time Data Analytics at Scale. Get real-time insights from all types of time series data with InfluxDB. Ingest, query, and analyze billions of data points in real-time with unbounded cardinality.
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AppImageKit
Package desktop applications as AppImages that run on common Linux-based operating systems, such as RHEL, CentOS, openSUSE, SLED, Ubuntu, Fedora, debian and derivatives. Join #AppImage on irc.libera.chat
both ryujinx and yuzu run natively
rpcs3 is also native
libretro cores will get you pretty far with retroarch (and retroachievements are pretty cool too), but for newer stuff you'll need to dive into standalone emus
slippi is available as an AppImage
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.