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DearPyGui
Dear PyGui: A fast and powerful Graphical User Interface Toolkit for Python with minimal dependencies
For example DearPyGUI seems promising to me. https://github.com/hoffstadt/DearPyGui
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JetBrains
Tell us how you use coding tools. You may win a prize! Are you a developer or a data analyst? Share your thoughts about your coding tools in our short survey and get a chance to win prizes!
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Slint
Discontinued Slint is a toolkit to efficiently develop fluid graphical user interfaces for any display: embedded devices and desktop applications. We support multiple programming languages, such as Rust, C++ or JavaScript. [Moved to: https://github.com/slint-ui/slint]
sixtyfps was mentioned not recently. I didn't give it a try, but ex-Qt devs are among founders in there. So project looks promising. Not really sure how mature it is. But I think few years ago it was heared already.