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Not OP, but one thing that surprised me was if you are doing rust Simd in a library, and part of the code is marked #[inline] but others are not you might see catastrophic performance regressions. We saw an issue where the SIMD version was over 10x slower because we missed marking one function as inline. Essentially rustc converted it from an intrinsic to a regular function call.
https://github.com/rust-lang/rust/issues/107617#issuecomment...
At that point it is better to have some kind of DSL that should not be in the main language, because it would target a much lower level than a typical program. The best effort I've seen in this scene was Google's Highway [1] (not to be confused with HighwayHash) and I even once attempted to recreate it in Rust, but it is still distanced from my ideal.
[1] https://github.com/google/highway
How does this compare to fastbase64[0]? Great article, I'm happy to see this sort of thing online. I wish I could share the author's optimism about portable SIMD libraries.
[0]: https://github.com/lemire/fastbase64