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But we're not stuck with one or the other. Python-JS interop has improved greatly in recent years with projects like Pyodide, JupyterLite, and PyScript. Often my strategy is to do the probability in Python and use JS for visualization, as you can see in this ability score calculator or this AnyDice-like interface.
Still, I chose Python for my Icepool dice probability package; compared to JS, Python has BigInts by default (you can append n to literals in JS, but it is a little annoying); and operator overloading, which allows for more compact and readable syntax.