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Theres also Py Spy, a profiling tool that can generate flame charts containing a mix of python and C (or C++) calls.
https://github.com/benfred/py-spy
It's worked really well for my needs
#284
> "Users can do [mixed mode] debugging with GDB (and/or other debuggers) and log the session in a notebook; in particular in order to teach.*
Your question is specifically about IDEs with support for mixed-mode debugging (with gdb), so I went looking for an answer:
https://wiki.python.org/moin/DebuggingWithGdb (which is not responsive and almost unreadable on a mobile device) links to https://fedoraproject.org/wiki/Features/EasierPythonDebuggin... , which mentions the py-list, py-up and py-down, py-bt, py-print, and py-locals GDB commands that are also described in * https://devguide.python.org/gdb/ **
> https://wiki.python.org/moin/PythonDebuggingTools Ctrl-F "gdb" mentions: DDD, pyclewn (vim), trepan3k (which is gdb-like and supports breaking at c-line and also handles bytecode disassembly)
> Apparently, GHIDRA does not have a debugger but there is a plugin for following along with gdb in ghidra called https://github.com/Comsecuris/gdbghidra [...] * https://github.com/Comsecuris/gdbghidra/blob/master/data/gdb... (zero dependencies)*
> https://reverseengineering.stackexchange.com/questions/1392/... lists a number of GUIs for GDB; including voltronnn:
>> There's Voltron, which is an extensible Python debugger UI that supports LLDB, GDB, VDB, and WinDbg/CDB (via PyKD) and runs on macOS, Linux and Windows. For the first three it supports x86, x86_64, and arm with even arm64 support for lldb while adding even powerpc support for gdb.
https://github.com/snare/voltron
> * https://developers.redhat.com/blog/2017/11/10/gdb-python-api... describes the GDB Python API.*
> https://pythonextensionpatterns.readthedocs.io/en/latest/deb... may be helpful [for writing-a-c-function-to-call-any-python-unit-test]
> The GDB Python API docs: https://sourceware.org/gdb/onlinedocs/gdb/Python-API.html
> The devguide gdb page may be the place to list IDEs with support for mixed-mode debugging of Python and C/C++/Cython specifically with gdb?