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steamtinkerlaunch
Linux wrapper tool for use with the Steam client for custom launch options and 3rd party programs
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If you mean using Nexus' Mod Manager, SteamTinkerLaunch handles installing Vortex through Proton. So you could always just use that as you already are used to.
ALSO if a mod has some kind of external dependency, like if it specifically mentions needing VisualC or .NET Runtime, Protontricks will be a lifesaver for installing these into Proton prefixes. Might not need it often, but could come in handy to know anyways.
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.