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Top 23 Python Framework Projects
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For the API, I will use the Django framework and other supporting libraries.
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Project mention: FastOpenAPI: Generate OpenAPI Schemas for Any Python Framework | dev.to | 2025-03-22
This project was inspired by FastAPI and aims to provide a similar developer-friendly experience
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Scrapy is a robust and scalable open-source web crawling framework. It is highly efficient for large-scale projects and supports asynchronous scraping.
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Project mention: Quick tip: Replace MongoDB® Atlas with SingleStore Kai in LlamaIndex | dev.to | 2025-01-21
The notebook is adapted from the LlamaIndex GitHub repo.
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textual
Lean TUI application framework for Python. Build sophisticated terminal user interfaces with a simple Python API. Run your apps in the terminal and a web browser.
Nice job, you should add it here: https://textual.textualize.io/#built-with-textual
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Python Telegram Bot Library: https://python-telegram-bot.org
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MkDocs-Material
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SaaSHub
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Reflex: Build your AI app's frontend and backend in Python. Check out the Reflex website’s implementation examples for AI image generation and chatbots.
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Project mention: Ask HN: How to do dead simple heartbeat monitoring? | news.ycombinator.com | 2024-05-06
Or apprise for a whole bunch of notifications.
https://github.com/caronc/apprise
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APIs are often the key to enabling interoperability between AML/KYC solutions and other systems. Design APIs following RESTful principles—using libraries like ExpressJs (JavaScript), Flask (Python), or Actix Web (Rust)—ensuring they are stateless and support the JSON/XML formats expected by most systems. Use Swagger to generate detailed documentation for RESTful APIs to facilitate integration and ensure your APIs are easily consumable by other systems. If you’re building GraphQL APIs, using tools like Apollo Server, Prisma, or Graphene will allow for self-documenting APIs (through GraphQL introspection).
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Objection is a runtime mobile exploration toolkit, powered by Frida. I wrote a blog post that explains what Frida is and how it can be setup on Android. You can find it from here.
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Recently, OpenAI released a generative AI project called openai-agents-python.
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backtesting.py
:mag_right: :chart_with_upwards_trend: :snake: :moneybag: Backtest trading strategies in Python.
Project mention: Show HN: High-Frequency Trading and Market-Making Backtesting Tool with Examples | news.ycombinator.com | 2024-06-21 -
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Project mention: Qiling: A True Instrumentable Binary Emulation Framework | news.ycombinator.com | 2024-04-01
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Project mention: Nameko: A Python Framework for Building Microservices | news.ycombinator.com | 2024-06-24
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multi-agent-orchestrator
Flexible and powerful framework for managing multiple AI agents and handling complex conversations
Project mention: Multi-Agent Orchestrator – Flexible framework for managing multiple AI agents | news.ycombinator.com | 2024-12-22 -
vidgear
A High-performance cross-platform Video Processing Python framework powerpacked with unique trailblazing features :fire:
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On-going open source project to reach to product-grad product.
Built with AdalFlow library: https://github.com/SylphAI-Inc/AdalFlow
Will including dataset creation, evaluation, and auto-prompt optimization
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NOTE:
The open source projects on this list are ordered by number of github stars.
The number of mentions indicates repo mentiontions in the last 12 Months or
since we started tracking (Dec 2020).
Python Framework discussion
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Building AI Agents: Semantic Integration of Structured and Unstructured Data using OpenAI Agent SDK
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Open Source: A Goldmine for Indie Hackers – Unleashing Creativity and Collaboration
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Langfun: A New Python Library Making LLMs Fun and Object-Oriented
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Django Codebase Updates: January 2025
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Chat with any GitHub Repo for free [video]
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A note from our sponsor - CodeRabbit
coderabbit.ai | 24 Mar 2025
Index
What are some of the best open-source Framework projects in Python? This list will help you:
| # | Project | Stars |
|---|---|---|
| 1 | Django | 82,809 |
| 2 | fastapi | 82,407 |
| 3 | Scrapy | 54,599 |
| 4 | llama_index | 40,107 |
| 5 | textual | 27,864 |
| 6 | python-telegram-bot | 27,164 |
| 7 | mkdocs-material | 22,557 |
| 8 | reflex | 22,092 |
| 9 | serve | 21,450 |
| 10 | sanic | 18,282 |
| 11 | apprise | 12,943 |
| 12 | Graphene | 8,155 |
| 13 | objection | 7,910 |
| 14 | openai-agents-python | 6,468 |
| 15 | backtesting.py | 6,142 |
| 16 | flower | 5,567 |
| 17 | qiling | 5,312 |
| 18 | Nameko | 4,728 |
| 19 | multi-agent-orchestrator | 4,406 |
| 20 | vidgear | 3,479 |
| 21 | rocketry | 3,321 |
| 22 | AdalFlow | 2,889 |
| 23 | PyFlow | 2,693 |
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