Top 3 Python cpe Projects

cve-search

1 2,202 8.5 Python

cve-search - a tool to perform local searches for known vulnerabilities (by cve-search)
vulnerablecode

2 472 8.6 Python

A free and open vulnerabilities database and the packages they impact. And the tools to aggregate and correlate these vulnerabilities. Sponsored by NLnet https://nlnet.nl/project/vulnerabilitydatabase/ for https://www.aboutcode.org/ Chat at https://gitter.im/aboutcode-org/vulnerablecode Docs at https://vulnerablecode.readthedocs.org/
InfluxDB

www.influxdata.com featured

Power Real-Time Data Analytics at Scale. Get real-time insights from all types of time series data with InfluxDB. Ingest, query, and analyze billions of data points in real-time with unbounded cardinality.
sbomnix

1 97 8.8 Python

A suite of utilities to help with software supply chain challenges on nix targets

Project mention: Wolfi: A community Linux OS designed for the container and cloud-native era | news.ycombinator.com | 2023-06-27

I'm not sure what you mean by "non-trivial" but here's a simple discord bot I wrote in python, that I distribute as an OCI image and that is built with Nix for both x86_64 and aarch64 linux via GitHub actions: https://github.com/starcraft66/attention-attention
There is no SBOM because I didn't bother publishing one but the way Nix builds derivations, you basically get the SBOM for free. You could use a tool like sbomnix[1] to trivially generate an SPDX-format SBOM from the nix derivation that builds the container image.
1: https://github.com/tiiuae/sbomnix

NOTE: The open source projects on this list are ordered by number of github stars. The number of mentions indicates repo mentiontions in the last 12 Months or since we started tracking (Dec 2020).