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Top 23 Python ai-assistant Projects
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gptme
Your agent in your terminal, equipped with local tools: writes code, uses the terminal, browses the web. Make your own persistent autonomous agent on top!
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tldw_server
tl/dw (Too Long, Didn't Watch): Your Personal Research Multi-Tool - a naive attempt at 'A Young Lady's Illustrated Primer' (Open Source NotebookLM)
Project mention: Show HN: OpenBrief – Local-first video downloader/summarizer | news.ycombinator.com | 2026-05-25Cool project! I built something similar a while back and then kept adding to it: https://github.com/rmusser01/tldw_server
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Project mention: Beyond package management: How Nix refactored my digital life | news.ycombinator.com | 2025-09-11
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Thoth
Thoth - Personal AI Sovereignty. A local-first AI assistant with integrated tools, a personal knowledge graph, voice, vision, shell, browser automation, scheduled tasks, health tracking, and messaging channels. Run locally via Ollama or add opt-in cloud models. Your data stays on your machine.
Project mention: Thoth v3.20.0 – Full Linux Support, MiniMax Integration, Reliability Upgrades | news.ycombinator.com | 2026-05-05 -
Athena-Public
The Linux OS for AI Agents — Persistent memory, structured reasoning, and governed autonomy for any LLM. Own the state. Rent the intelligence.
Project mention: Show HN: Athena – A sovereign, local-first AI agent framework (anti-subscription | news.ycombinator.com | 2026-02-05 -
OpenAI-sublime-text
First class Sublime Text AI assistant with gpt-5, Opus 4.6, Gemini 3 and ollama support!
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Project mention: I Built an Open-Source Bridge That Turns Claude Code Into a REST API | dev.to | 2026-03-23
There are some great open-source wrappers like coder/agentapi and claude-code-api, but they're designed for local use only. I needed something that works remotely too — without having to set up reverse proxies, TLS certificates, and authentication from scratch.
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google-bard-api
This project provides a FastAPI wrapper for interacting with Google Bard, a conversational AI by Google. It allows users to send messages to Google Bard and receive responses through a simple API.
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M.I.L.E.S
M.I.L.E.S, a GPT-4-Turbo voice assistant, self-adapts its prompts and AI model, can play any Spotify song, adjusts system and Spotify volume, performs calculations, browses the web and internet, searches global weather, delivers date and time, autonomously chooses and retains long-term memories. Available for macOS and Windows.
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k8s-mcp-server
K8s-mcp-server is a Model Context Protocol (MCP) server that enables AI assistants like Claude to securely execute Kubernetes commands. It provides a bridge between language models and essential Kubernetes CLI tools including kubectl, helm, istioctl, and argocd, allowing AI systems to assist with cluster management, troubleshooting, and deployments
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agentor
Open source version of Claude Managed Agents. Fastest way to build and deploy reliable AI agents, MCP tools and agent-to-agent.
Project mention: Show HN: Built an open-source SDK to simplify tool authentication for AI Agents | news.ycombinator.com | 2025-10-11 -
kobold_assistant
Like ChatGPT's voice conversations with an AI, but entirely offline/private/trade-secret-friendly, using local AI models such as LLama 2 and Whisper
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odin-slides
This is an advanced Python tool that empowers you to effortlessly draft customizable PowerPoint slides using the Generative Pre-trained Transformer (GPT) of your choice. Leveraging the capabilities of Large Language Models (LLM), odin-slides enables you to turn the lengthiest Word documents into well organized presentations.
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zyron-assistant
⚡ A local, privacy-focused AI desktop assistant for Windows. Control your PC remotely via Telegram or locally with Voice commands. Powered by Ollama.
Project mention: Built a desktop assistant [fully local] for myself without any privacy issue | news.ycombinator.com | 2026-02-05 -
Project mention: Show HN: We built Cursor, but for data transformations [Open Source] | news.ycombinator.com | 2026-04-22
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kai
Kai is a local, Telegram-first personal engineering system: a persistent AI collaborator with repo-aware coding, memory, scheduling, PR review, and multi-backend resilience. Your machine, your data, your rules. (by dcellison)
Project mention: Show HN: Kai – A Telegram bot that turns Claude Code into a personal dev asst | news.ycombinator.com | 2026-02-16 -
MCP-OpenStack-Ops
90+ production-safe OpenStack tools for AI agents via MCP. Project-scoped & read-only by default. Works with Claude, Open WebUI & any MCP client. FastMCP + OpenStack SDK. Available on PyPI, Docker Hub & Smithery.
GitHub: https://github.com/call518/MCP-OpenStack-Ops
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splaa
SPLAA is an AI assistant framework that utilizes voice recognition, text-to-speech, and tool-calling capabilities to provide a conversational and interactive experience. It uses LLMs available through Ollama and has capabilities for extending functionalities through a modular tool system.
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Heym
Self-hosted AI workflow automation visual canvas, agents, RAG, HITL, MCP, and observability in one runtime.
This is the problem we are working on with Heym.
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Open-Sable
Open-Sable is a local-first autonomous agent framework with AGI-inspired cognitive subsystems (goals, memory, metacognition, tool use). It can run continuously on your machine, integrate with chat interfaces like Telegram, execute real tasks safely, and keep data private by default.
Project mention: Show HN: Open-Sable, Self-hosted cognitive AI agent with memory and 127 tools | news.ycombinator.com | 2026-03-07 -
AI-Voice-Activated-Personal-Assistant
Your Very Own Personal "Iron Man Jarvis" - A Voice activated LLM-powered Personal Assistant That has Conversations With You!
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arxiv-mcp-server
MCP server for arXiv.org - Search, analyze, and export academic papers with AI assistants. Features advanced paper discovery, citation analysis, trend tracking, and multi-format exports.
NOTE:
The open source projects on this list are ordered by number of github stars.
The number of mentions indicates repo mentiontions in the last 12 Months or
since we started tracking (Dec 2020).
Python ai-assistant discussion
Python ai-assistant related posts
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Multi-Agent Systems Need More Than a Prompt
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CorvinOS – self-hosted OS for AI agents, compliance built into the runtime
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CorvinOS – an agentic OS where GDPR/EU AI Act compliance can't be switched off
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CorvinOS – a self-hosted agentic OS which enforce EU AI Act 2026 by design
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Making JetBrains AI Assistant work with Gemini: v0.0.2 is out
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An AI agent that must produce evidence before it can say "done"
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Show HN: OpenBrief – Local-first video downloader/summarizer
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A note from our sponsor - SaaSHub
www.saashub.com | 21 Jul 2026
Index
What are some of the best open-source ai-assistant projects in Python? This list will help you:
| # | Project | Stars |
|---|---|---|
| 1 | gptme | 4,361 |
| 2 | tldw_server | 1,423 |
| 3 | mcp-nixos | 766 |
| 4 | Thoth | 663 |
| 5 | Athena-Public | 516 |
| 6 | OpenAI-sublime-text | 467 |
| 7 | claude-code-api | 315 |
| 8 | google-bard-api | 249 |
| 9 | M.I.L.E.S | 232 |
| 10 | k8s-mcp-server | 213 |
| 11 | agentor | 190 |
| 12 | kobold_assistant | 161 |
| 13 | odin-slides | 150 |
| 14 | zyron-assistant | 117 |
| 15 | visitran | 69 |
| 16 | kai | 35 |
| 17 | MCP-OpenStack-Ops | 35 |
| 18 | augini | 33 |
| 19 | splaa | 29 |
| 20 | Heym | 28 |
| 21 | Open-Sable | 23 |
| 22 | AI-Voice-Activated-Personal-Assistant | 22 |
| 23 | arxiv-mcp-server | 19 |
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