s2disasm VS cuda-the-spire

The game has been disassembled, so you don't even need to bother hacking the game's ROM. I guess you only have to replace assets and build the game, basically.

specifically leaked, or just available? Sonic 2 has a very nice disassembly https://github.com/sonicretro/s2disasm

I found this seed primarily using StS CUDA code to sieve for seeds that get Neow's Lament on floor 1 and can buy Juzu Bracelet at the first shop because of the Sssserpent event while also avoiding event node combats. I accounted for unlock manipulation (changing the size of the common relic pool), along with details of the Java random number generator's shuffle method to increase the throughput of seeds.

GPU-accelerated seed searching for high-performance searches such as the first mathematically proven unwinnable seed, and

Depending on the player's path, the probability of hitting a shop or treasure is usually between 2% and 8%, and in this one, we get lucky 8 times in a row! We found this seed by running a GPU-accelerated search. The run also minimizes the number of rest sites visited, because they have a fixed-time animation that cannot be avoided. It is theoretically possible to get one more shop/treasure room instead of the 1st rest site, with enough luck. Perhaps some other day!

I agree that Neow options on floor 0 also make it extremely difficult to find an unwinnable seed with this criterion. If I dug deeper into the Jaw Worm AI, I could probably put together a GPU-accelerated sieve for candidate seeds in the CUDA code I've been playing with.