protonhax VS ProtonUp-Qt

Yes, see https://github.com/jcnils/protonhax

On Steam, since it uses Proton, the only way of running an .exe on the prefix would be using ProtonHax.

I've used Cheat Engine with Elden Ring. I used https://github.com/jcnils/protonhax to run CE within the wine instance started by Proton. But I think I used the x86_64 version. You specifically talk about a speed hack. Have you tried other cheats? If it's specifically the speed hack that doesn't work, it may be broken with the current version of whatever game you're trying to hack.

How did you install cheat engine? You need to run it in the same proton/wine prefix as your target process. I use protonhax for steam games, but there are other ways. If you're targeting native linux processes, look into ceserver.

try protonhax, it works with bakkesmod

Using protonhax, I got CE to work.

Lutris is a launcher for applications that run on Linux, that's the most comprehensive answer. It is highly configurable and supports scripting. Probably the most common use is launching non-steam Windows games with Wine and DXVK/VKD3D (I recommend a tool called ProtonUp-Qt for managing versions of this software). However, it can be configured to launch just about anything, including native Linux executables etc. Many popular titles will have scripts that automate the installation and setup, making them plug and play (if the script is good, that is). But everything the script does can be done manually too.

Try Installing proton up qt (haven’t tried it yet, I have the same issues as you). You can find it here (use dxvk): https://davidotek.github.io/protonup-qt/

Easiest way is to ise ProtonUp-Qt: https://github.com/DavidoTek/ProtonUp-Qt

Install ProtonUp-Qt from the Discover store and open it

/// protonGE downloader ensures you have the latest version

In the discover store you can find https://davidotek.github.io/protonup-qt/ that will download the latest.

Try installing it through Steam instead of using Wine directly. Mine is currently set to "Force the use of a specific Steam Play compatibility tool" and GE-Proton7-41, so try installing that one if none of the Proton versions that come with the Steam client works. Installing a custom version of Proton is fairly simple if you know the command line, basically just unpack it into the right folder. But if you prefer graphical tools you can use ProtonUp-Qt instead.

I'd try that since it's something you haven't tried at least. Check the first comment - all you have to do is install protonUp-Qt and then launch it. Use protonup to install Proton GE 7-55. Then, when you go to steam (might require a restart, don't remember) in the compatibility settings for the game you can set it to the Proton GE version.

Bit late but luxtorpeda has gzdoom as an option along with qzdl for launching with mods. You just gotta install protonup-qt from the discover store in desktop mode. A quick YouTube/Google search can show you how but that's the rough gist of it.