gnomad-browser VS PostHog

try one of these: GnomAD (https://gnomad.broadinstitute.org/) 1000 Genomes (http://browser.1000genomes.org) dbSNP (http://www.ncbi.nlm.nih.gov/snp)

Maybe you can ask the opposite question; what are the bounds of of a functional human being. https://gnomad.broadinstitute.org/ GnomAD is a aggregation of healthy human genetic sequences which was primarily built on the aggregated control groups of many genetic sequencing studies. There are studies of this data analysing the co-occurrence of variants in gnomAD which may help.

Maybe something like this? https://promethease.com/ Clinvar for variants that might be of clinical relevance. https://gnomad.broadinstitute.org/ for allele frequencies & some info about variants.

You could look at aggregation databases such as gnomad https://gnomad.broadinstitute.org/ anything with a frequency incompatible with the disease is likely non pathogenic

Broad Institute of MIT and Harvard | Cambridge, MA | Frontend Software Engineer | REMOTE or HYBRID (New England area)

We are hiring a frontend developer to help lead the next phase of the gnomAD browser, a web application for displaying the world's largest collection of human genome/exome sequences. https://gnomad.broadinstitute.org. Looking for applicants who are excited about data visualization and designing complex interfaces for scientific research.

Apply here: http://broad.io/cq7dw8

Broad Institute of MIT and Harvard | New England | Software Engineer | REMOTE/HYBRID

Our team is focused on building the tools necessary to visualize and interpret massive data sets of human genetic variation and functional genomic information. We have developed gnomAD (https://gnomad.broadinstitute.org), the world’s largest public reference dataset of human exomes and genomes. gnomAD has become one of the most widely used resources in the field, and is now the default reference database for virtually all clinical interpretation pipelines, as well as a standard analysis resource for a wide variety of genetic and biological studies. We estimate gnomAD has contributed to the clinical diagnosis of over 2 million patients with genetic disorders.

Your role will be to maintain the gnomAD browser, our open source web application for exploring gnomAD and related datasets, and develop new scientific functionality as we continue to grow to over 1 million human samples. You will work with a team of software engineers, computational biologists and clinical and research users to develop new features and visualizations that incorporate user feedback. Software engineering skills and an interest in user interface design and data visualization are key. Basic familiarity with genomics and DNA sequencing data is preferred, but not required. Most importantly, the ideal candidate will have enthusiasm for playing a critical role in a team-oriented project and learning new domains.

Minimum Requirements

If you're talking about humans, start with gnomAD: https://gnomad.broadinstitute.org/

It would be a shame not to mention PostHog as the telemetry provider we are using, since it turned out to be extremely useful. Because it is hard to find people who will talk with you about your product, gathering statistics gave us a much greater insight into our users.

6- PostHog

Hi HN, PostHog employee here. I'm working on our Web Analytics product, which is currently in beta. It's fun to see us mentioned here :)

I should mention that we have a ton of SDKs (see https://posthog.com/docs/libraries) for back end frameworks and languages, so if you wanted to use PostHog without any client-side JS you could send pageviews and other events manually, but for the vast majority of people it makes more sense to use our JS snippet.

Hijacking this comment to share the roadmap for web analytics https://github.com/PostHog/posthog/issues/18547. It's very much in the launch-early-and-be-embarassed phase, but I would love to hear any feedback or suggestions that people have, particularly if you're already a PostHog user.

how's this different than https://posthog.com/ ?

PostHog - Open Source Alternative to Mixpanel

Don't insert the logs/events/analytics into your Application DB. Usually, you send those to specialist datastores (OLAP etc) that process such high volume of data. You can use something like clickhouse [0] for example or use 3rd party SAAS solutions like posthog [1] etc that are built on top of clickhouse

[0] https://clickhouse.com

[1] https://posthog.com

I may use Flask-Admin initially to offload the "CRUD" operations to have an initial prototype fast but then drop it ASAP because I don't want to write a "flask-admin application" to fight against later on. If the application is mainly "CRUD", then Flask-Admin is suitable.

Now...

Would you do a breakdown/list of all the jobs you've done by sector/vertical and by function/role and by application functionality?

- [0]: https://flask.palletsprojects.com

- [1]: https://flask-admin.readthedocs.io/en/latest

- [2]: https://flask.palletsprojects.com/en/2.3.x/patterns/celery

- [3]: https://sentry.io

- [4]: https://posthog.com

- [5]: https://www.docker.com

PostHog | Remote (US/Europe timezones) | Full stack engineer, technical ex-founder, tech lead | https://posthog.com

PostHog is the only open-source Product OS, combining product analytics, session recordings, feature flags, cdp and a data warehouse in one.

We have a culture of written async communication (see our handbook [0]), lots of individual responsibility and an opportunity to make a huge impact. Being fully remote means we're able to create a team that is truly diverse. We're based all over the world, and the team includes former YC founders, CTOs turned developers and recent grads.

To apply see https://posthog.com/careers or email us [email protected]

[0] https://posthog.com/handbook/

There seems to be posthog.com analytics and AB or feature flag functionality that is blocked by adblockers. Probably that?