gnomad-browser
metamask-extension
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gnomad-browser | metamask-extension | |
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15 | 1,137 | |
78 | 11,467 | |
- | 2.2% | |
9.7 | 10.0 | |
3 days ago | 5 days ago | |
TypeScript | JavaScript | |
MIT License | GNU General Public License v3.0 or later |
Stars - the number of stars that a project has on GitHub. Growth - month over month growth in stars.
Activity is a relative number indicating how actively a project is being developed. Recent commits have higher weight than older ones.
For example, an activity of 9.0 indicates that a project is amongst the top 10% of the most actively developed projects that we are tracking.
gnomad-browser
- All identified polymorphisms in a given gene, how to find?
- AskScience AMA Series: We're human genetics researchers here to discuss connections between people in different geographical regions. Ask us anything!
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Converting 23&Me raw data into a format usable by Admixtools 2
try one of these: GnomAD (https://gnomad.broadinstitute.org/) 1000 Genomes (http://browser.1000genomes.org) dbSNP (http://www.ncbi.nlm.nih.gov/snp)
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What is the maximum number of human?
Maybe you can ask the opposite question; what are the bounds of of a functional human being. https://gnomad.broadinstitute.org/ GnomAD is a aggregation of healthy human genetic sequences which was primarily built on the aggregated control groups of many genetic sequencing studies. There are studies of this data analysing the co-occurrence of variants in gnomAD which may help.
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Insights from personal sequencing data I can explore.
Maybe something like this? https://promethease.com/ Clinvar for variants that might be of clinical relevance. https://gnomad.broadinstitute.org/ for allele frequencies & some info about variants.
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What are some non-pathogenic alleles of the SNCA gene, or how do I find them?
You could look at aggregation databases such as gnomad https://gnomad.broadinstitute.org/ anything with a frequency incompatible with the disease is likely non pathogenic
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Ask HN: Who is hiring? (March 2022)
Broad Institute of MIT and Harvard | Cambridge, MA | Frontend Software Engineer | REMOTE or HYBRID (New England area)
We are hiring a frontend developer to help lead the next phase of the gnomAD browser, a web application for displaying the world's largest collection of human genome/exome sequences. https://gnomad.broadinstitute.org. Looking for applicants who are excited about data visualization and designing complex interfaces for scientific research.
Apply here: http://broad.io/cq7dw8
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Ask HN: Who is hiring? (February 2022)
Broad Institute of MIT and Harvard | New England | Software Engineer | REMOTE/HYBRID
Our team is focused on building the tools necessary to visualize and interpret massive data sets of human genetic variation and functional genomic information. We have developed gnomAD (https://gnomad.broadinstitute.org), the world’s largest public reference dataset of human exomes and genomes. gnomAD has become one of the most widely used resources in the field, and is now the default reference database for virtually all clinical interpretation pipelines, as well as a standard analysis resource for a wide variety of genetic and biological studies. We estimate gnomAD has contributed to the clinical diagnosis of over 2 million patients with genetic disorders.
Your role will be to maintain the gnomAD browser, our open source web application for exploring gnomAD and related datasets, and develop new scientific functionality as we continue to grow to over 1 million human samples. You will work with a team of software engineers, computational biologists and clinical and research users to develop new features and visualizations that incorporate user feedback. Software engineering skills and an interest in user interface design and data visualization are key. Basic familiarity with genomics and DNA sequencing data is preferred, but not required. Most importantly, the ideal candidate will have enthusiasm for playing a critical role in a team-oriented project and learning new domains.
Minimum Requirements
- Ask HN: How to be my own genetic disease researcher for my partner?
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How to check if a discovered mutation is novel or was discovered before ?
If you're talking about humans, start with gnomAD: https://gnomad.broadinstitute.org/
metamask-extension
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How to Register a Smart Contract to Mode SFS with Hardhat.
Have an Ethereum wallet, preferably Metamask installed.
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Assign a smart contract to an existing SFS NFT with Thirdweb deployment
A Metamask Account.
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I turned my open-source project into a full-time business
Plenty of projects are source-available, but not open source, and get tons of issues, and even contributions (https://github.com/MetaMask/metamask-extension off the top of my head)
- ¡Entiende las Attestations! Guía definitiva📚
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Understand Attestations! Ultimate Guide📚
You can create an attestation based on an existing schema or create your own. Schemas define the format in which attestations will be made, and in this case, we will use the Is Human schema to attest that the owner of a certain address is human. For this example, you only need to connect your Metamask wallet (or any wallet) to Scroll Sepolia, then enter the address you want to attest and click Make attestation. You can choose whether you want the off-chain attestation, i.e., free, obtained only by signing a transaction. Alternatively, you can choose to make it on-chain and pay for the transaction to make it public and connect it to smart contract logic. In this case, you will need to obtain funds in Scroll Sepolia through a Scroll Sepolia Faucet.
- Esta fórmula mueve billones 💰 en DeFi
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Projects to contribute to
Metamask (9000 GitHub Stars) https://github.com/MetaMask/metamask-extension
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Fe or Solidity, which is better?
For this tutorial you will need Metamask or other wallet of your choice, with Scroll Sepolia funds that you can get from a Sepolia faucet and then bridge them to L2 using the Scroll Sepolia bridge. Alternatively, you can use a Scroll Sepolia Faucet to get funds directly on L2.
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Sovereign Mode: Access Your Wallet Using Safe.global web app
16) Open Metamask app. In this instruction we will use Metamask extension for Chrome browser.
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Why Bother with uBlock Being Blocked in Chrome? Time to Switch to Firefox
> I get a 3-5 sec lag on launch [0] as it prepares the browser to block ads.
uBO is typically ready in a fraction of second, so "3-5 sec" is not normal. In Firefox all extensions sit in the same process, so it's possible another extension is preventing uBO to be ready in a timely manner, this has happened[1].
[1] https://github.com/MetaMask/metamask-extension/issues/13163
What are some alternatives?
webviz - web-based visualization libraries
Selenium WebDriver - A browser automation framework and ecosystem.
haystack - :mag: LLM orchestration framework to build customizable, production-ready LLM applications. Connect components (models, vector DBs, file converters) to pipelines or agents that can interact with your data. With advanced retrieval methods, it's best suited for building RAG, question answering, semantic search or conversational agent chatbots.
rainbow - 🌈‒ the Ethereum wallet that lives in your pocket
aioli - Framework for building fast genomics web tools with WebAssembly and WebWorkers
eth-gasnow-extention - GasNow extension for browser
Baserow - Open source no-code database and Airtable alternative. Create your own online database without technical experience. Performant with high volumes of data, can be self hosted and supports plugins
hicetnunc - hicetnunc UI/UX
FrameworkBenchmarks - Source for the TechEmpower Framework Benchmarks project
opensea-js - TypeScript SDK for the OpenSea marketplace
threatbus - 🚌 Threat Bus – A threat intelligence dissemination layer for open-source security tools.
cardano-node - The core component that is used to participate in a Cardano decentralised blockchain.