cuda-the-spire VS SeedSearch

I found this seed primarily using StS CUDA code to sieve for seeds that get Neow's Lament on floor 1 and can buy Juzu Bracelet at the first shop because of the Sssserpent event while also avoiding event node combats. I accounted for unlock manipulation (changing the size of the common relic pool), along with details of the Java random number generator's shuffle method to increase the throughput of seeds.

GPU-accelerated seed searching for high-performance searches such as the first mathematically proven unwinnable seed, and

Depending on the player's path, the probability of hitting a shop or treasure is usually between 2% and 8%, and in this one, we get lucky 8 times in a row! We found this seed by running a GPU-accelerated search. The run also minimizes the number of rest sites visited, because they have a fixed-time animation that cannot be avoided. It is theoretically possible to get one more shop/treasure room instead of the 1st rest site, with enough luck. Perhaps some other day!

I agree that Neow options on floor 0 also make it extremely difficult to find an unwinnable seed with this criterion. If I dug deeper into the Jaw Worm AI, I could probably put together a GPU-accelerated sieve for candidate seeds in the CUDA code I've been playing with.

I know of something that goes in the opposite direction -- looks for a seed that matches certain conditions, instead of what you want (looks up conditions that are true for a specific seed). So, it should be theoretically possible, at least?

Finally, I used Arbiter's SeedSearch mod to eyeball the routes to check for potions, card rewards, etc.

Gamerpuppy's project is MUCH MUCH faster than this but isn't built into the game, so check that out if you're interested in finding seeds in a different but faster way. ForgottenArbiter's project will find more specific paths to find a seed that you want and it will tell you the path you should take for your chosen criteria and you can be much more specific with your filters.

most seeds are found randomly yes, there's a document with a bunch of pandora box swaps (on PC) but if that's not what you're asking there are things like https://github.com/ForgottenArbiter/SeedSearch

You could feed the seed into Seedsearch to see what the last boss is. Just configure it to not search for anything in particular. Or you could use Achievment enabler to enable them even when using a seeded or modded run.

You could always try Seed Search to find a run with a sufficiently strong start. It probably is easier than you think, with access to infinites, buffer stacks, intangibility, etc.