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I... recently got that working: https://github.com/digikar99/py4cl2/tree/master/cffi - Yes, CFFI! Yes, passing CL array data by reference!
I think the closest is cl-autowrap. I can imagine a higher level wrapper around it by which it can translate the python header file into the CL counterpart, although I'm not sure how much work the translation might entail. Also, because python and lisp semantics can differ considerably, the generated code might be trying to do weird things - again an issue of translation.
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