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Open source UI framework written in Python, running on Windows, Linux, macOS, Android and iOS
As for creating your own GUI library, you'll probably need to find a way to interface with SDL or X11 libraries -- you can see how kivy does it here: kivy/_window_sdl2.pyx at master · kivy/kivy (github.com) . This isn't trivial at all and I wouldn't really recommend it to a beginner, but if you're motivated enough, go for it.
Dear PyGui: A fast and powerful Graphical User Interface Toolkit for Python with minimal dependencies
If you just want a GUI that looks and acts differently than Tkinter, I would recommend Dear PyGui, an easy to use and fast GUI (no dependencies whatsoever and not a wrapper for Tkinter in any way).
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Easy to use Python library for creating 2D arcade games.
Ok, first of all, creating a GUI is a massive undertaking that takes advanced developers years of consistent work. However if you want to create an app with a few image buttons that don't look like your average GUI, you could use libraries pyglet, arcade and pygame. These libraries allow you to draw and put images on the screen and provide an API for mouse and keyboard events, so you at least don't have to deal with low-level coding. Arcade in particular is aimed at the beginning developer with a focus on documentation and examples.
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