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You should be fine as long as you follow the API access rules. As other have mentioned there may be some rate-limiting but in my tests I was fine fetching every 15-20min (and sometimes much more often during testing, but I was at most at 2-3 calls per minute).
If you want to (continuously) sync data from a subreddit into your DB you can try this open source tool (disclaimer, I am an author): https://github.com/NangoHQ/nango There is also an example that shows how to sync the latest posts from a subreddit with it.
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.