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SaaSHub
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best-of-jupyter
🏆 A ranked list of awesome Jupyter Notebook, Hub and Lab projects (extensions, kernels, tools). Updated weekly.
Check out https://github.com/leanprover-community/mathlib . Sure, it's not really a CAS but CAS algorithms could be added to it where applicable, since Lean is a constructive system and can thus express formally verified computations.
And the free version has a neat open source fork that adds features: https://github.com/MCPI-Revival/minecraft-pi-reborn
The existence of https://github.com/robertylewis/mathematica makes me think it's more likely to go in the other direction, where you treat powerful tools as untrusted oracles which produce certificates that Lean then verifies.
Desmos has open source library called MathQuill, which converts typed chars to mathematical representation similar to Mathematica. Sure there is some "programming statements" like (La)TeX like syntax there, but so does Mathematica too.
[1]: http://mathquill.com/
There are Jupyter kernels for Python, Mathics, Wolfram, R, Octave, Matlab, xeus-cling, allthekernels (the polyglot kernel). https://github.com/jupyter/jupyter/wiki/Jupyter-kernels