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I'm not a python expert, but I've heard good things about PyQT. You might want to check it out. You can then use PyPDF to read/write PDF files.
Do you know JavaScript? With this, you could support Windows, Mac, & Linux and write it all in JavaScript. Consider combining it with this.
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.