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I have not so much experience, but I will share it. My project structure contains two folders - package folder (named as same as package) and "tests/". In tests I don't use relative imports. I run tests on raw files (same for coverage). I don't know how you can run tests on built package, since it not exposes internals (or it does?). I use all of this in my python package called Ndnt.
See https://github.com/cjolowicz/cookiecutter-hypermodern-python for a template and https://cjolowicz.github.io/posts/hypermodern-python-01-setup/ for some background explanation.