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Try using dxvk async for single player games, it allows for async shader compilation which vastly reduces the stuttering you're talking about but also broke some MP games because anti-cheat software sucks.
Speaking as someone who plays a lot of retro games, you're almost always better off running one of the already existing software API converters even on AMD or nVidia hardware these days if there's no open-source engine reimplementation that allows you to just run the game with modern code and other tweaks to help modern systems along. (eg. OpenRCT2, Simitone, OpenMW, etc) There's a lot of reasons as to why but essentially it all boils down to the simple fact that the older versions of DX and OpenGL aren't fully supported on modern GPUs, they're supported and probably tested to a certain degree but they're also a much lower priority than say, making sure the hot new FPS launching next month has a driver update that ensures it'll work well.
The Sims 1 - Can be made to work flawlessly on modern systems with either dgvoodoo2 or the alternative DDrawCompat, I recommend installing either one via the widescreen patcher as it also allows you to force the game to run at modern resolutions. (Although things get a tad small at 4k, I recommend a maximum resolution of 1080p and just using full-screen FSR for any required upscaling.)