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DearPyGui
Dear PyGui: A fast and powerful Graphical User Interface Toolkit for Python with minimal dependencies
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The microblogging application developed in my Flask Mega-Tutorial series. This version maps to the 2024 Edition of the tutorial.
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DearPyGui features your use case. If you want something simpler, go for streamlit, it's really easy and you will get your prototype in no time.
If so, one approach may be to abandon matplotlib for something like bokeh. Bokeh allows you to add many of the classical GUI elements (slider bars, radio buttons, etc). Depending on your needs, it can either make HTML files with your plots or with a little more work you can set it up as a server.
DearPyGui features your use case. If you want something simpler, go for streamlit, it's really easy and you will get your prototype in no time.
also checkout gradio, easy to get started and has been used for apps like text to image generation: https://huggingface.co/spaces/kuprel/min-dalle
There's always the flask mega tutorial, or various other simpler ones online.