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The use of tools like Finicky (https://github.com/johnste/finicky) have made it pretty easy for me segregate certain workloads to certain browsers (as long as the links are opened from outside of the current browser).
Safari is my daily driver, but I only take Google Meet meetings in Chrome and Teams meetings in Edge. I’ve also forced certain JIRA URLs to different browsers (Firefox or Edge, depending), because I have to be logged in as particular users for them.
I rarely use other browsers for anything else, but will occasionally test things in them—but using the separate browsers has been really good for segregating certain classes of work.
FWIW qutebrowser can disable JS (and also many other settings) per domain, though not on an as finegrained level as uMatrix.
However, there is this: https://gitlab.com/jgkamat/jmatrix
It's quite a hack and I have no idea where it is UI-wise, but it seems to work for some people at least.