Is there any software that can predict if two amino acid sequences would interact?

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  • alphafold

    Open source code for AlphaFold.

    • Not sure what the chimerax plugin does, but you can run alphafold multimer yourself: https://github.com/deepmind/alphafold

  • ColabFold

    Making Protein folding accessible to all!

    • a word of warning, the requirements are pretty high, if the sequences are not too long try one of the notebooks: https://github.com/sokrypton/ColabFold

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  • af2complex

    Predicting direct protein-protein interactions with AlphaFold deep learning neural network models.

    • Also, I saw a "AF2Complex" add-on to AlphaFold 2 which seems to do exactly what I'm looking for, but I don't think that it's available on ColabFold yet and I don't have TB storage available. I'm not expecting you to know this, but is there any way to run an AF2 add-on on Colab?

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