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Phaser
Discontinued Phaser is a fun, free and fast 2D game framework for making HTML5 games for desktop and mobile web browsers, supporting Canvas and WebGL rendering. [Moved to: https://github.com/phaserjs/phaser] (by photonstorm)
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SurveyJS
Open-Source JSON Form Builder to Create Dynamic Forms Right in Your App. With SurveyJS form UI libraries, you can build and style forms in a fully-integrated drag & drop form builder, render them in your JS app, and store form submission data in any backend, inc. PHP, ASP.NET Core, and Node.js.
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BabylonJS
Babylon.js is a powerful, beautiful, simple, and open game and rendering engine packed into a friendly JavaScript framework.
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PixiJS
The HTML5 Creation Engine: Create beautiful digital content with the fastest, most flexible 2D WebGL renderer.
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angular-rpg-game-engine
A 2D game engine for creating room-based sneak/action games with puzzle elements
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InfluxDB
Power Real-Time Data Analytics at Scale. Get real-time insights from all types of time series data with InfluxDB. Ingest, query, and analyze billions of data points in real-time with unbounded cardinality.
My idea is a bit more complex than Agar.io, it will involve more physics and maybe AI, plus a complex database besides other server dependent minor features. With the research I'm doing in addition to the debate in this post, I've decided that for now Phaser is the best tool for my project. Tomorrow I start it.
My old HTML5 multiplayer project that used Express, mongoDB, socket.io and Three.JS - https://www.youtube.com/watch?v=cJcr09qIVrI
ThreeJS and BabylonJS for 3D
ThreeJS and BabylonJS for 3D
PixiJS and Phaser for 2D
Also check Colyseus. Bit similar multiplayer server framework and built on top of Node.js/TypeScript. https://github.com/colyseus/colyseus
I myself am currently using LittleJS, and it's just amazing for me, as it sorts out the core engine & rendering logic, but I can easily reuse and plug in any sort of other libraries/old scripts from other games at need: https://github.com/KilledByAPixel/LittleJS
Another great, more advanced option than littleJS, looks to be ShakuJS: https://github.com/RonenNess/Shaku/tree/main/lib