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Most of the issues are with GPU support. Some libraries still struggle with it AFAIU but I don't use GPU much. M1 native is mostly good everywhere, except Pyqt + Qt 5 (Qt6 is native, but some libraries don't support it yet), But for those you can just start a bash shell under intel emulation and all is fine. Performances do take a hit take hit, but are still better in M1+emulation intel than native on my old mac.
Glad to help, we’re slowly open sourcing more stuff. But here is an example project written on both architectures and deployed to AKS. https://github.com/binkhq/api-reflector
Some stats from my dataset on PyPI packages:
I use the M1 version of miniforge (https://github.com/conda-forge/miniforge) and I'm able to create osx-64 python envs. I just explicitly set the right channel when installing a package, for example : conda install -c conda-forge/osx-64 python=3.9