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pytermgui
Python TUI framework with mouse support, modular widget system, customizable and rapid terminal markup language and more!
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Gooey is an interesting tool that may get you most of the way to what you want. It creates a GUI automatically from the same set of directives you would use to set up a command line utility (argparse). https://github.com/chriskiehl/Gooey
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.