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InfluxDB
Power Real-Time Data Analytics at Scale. Get real-time insights from all types of time series data with InfluxDB. Ingest, query, and analyze billions of data points in real-time with unbounded cardinality.
It can use any type of alert supported by https://github.com/jwiegley/alert
Emacs diary will give appointment reminders - ring the bell and show a popup window in emacs. As far as desktop notifications go - why wouldn't you use Google Calendar? Or Outlook? Org Gcal will sync Google Calendars in an Org document, and it's bidirectional. You can send Org headlines as calendar events as well as receive events from GC.
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.