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At the moment Pydub looks like the closest match, but if it requires an ffmpeg install it's going to be a problem for pyinstaller building .exes/.apps. Same for some PortAudio wrappers I've found.
check out https://github.com/belangeo/pyo
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.