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Avisynth only, but if you want something more IDE like, I'm a big fan of AvsPmod: https://github.com/gispos/AvsPmod (actively maintained fork)
Not a full blown GUI, but it shows you a video preview, syntax highlighting, function definitions for plugins, etc. It doesn't support Vapoursynth, but you can program macros in Python.
NOTE:
The number of mentions on this list indicates mentions on common posts plus user suggested alternatives.
Hence, a higher number means a more popular project.